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Lilly’s Humalog® 200 units/mL KwikPen® Now Available in U.S. Pharmacies

Aug 21, 2015

First and only concentrated mealtime insulin analog…

Humalog® 200 units/mL KwikPen® (insulin lispro 200 units/mL; U-200), the first and only concentrated mealtime insulin analog in the U.S., is now available in pharmacies. Humalog U-200 KwikPen is a prefilled pen containing a concentrated formulation of Lilly’s rapid-acting insulin Humalog® (insulin lispro 100 units/mL) to improve glycemic control in people with type 1 and type 2 diabetes. It is intended for people who are already taking mealtime insulin.


altHumalog U-200 KwikPen holds twice as many units of insulin (600 units vs. 300 units) as the U-100 formulation in the same three-milliliter cartridge volume, offering patients a pen that lasts longer, which facilitates fewer pen changes every month. This may help patients who require higher daily doses of mealtime insulin fit their treatment into their lives.

“This is an important new option for many people with diabetes,” said David Kendall, M.D., vice president, Medical Affairs, Lilly Diabetes. “Like everyone else, people with diabetes have busy lives. More rapid-acting insulin in a single pen may help patients worry less about running out when their plans change unexpectedly.”

The most common side effect of Humalog is severe hypoglycemia (low blood sugar) that may cause unconsciousness, seizures and death. Humalog U-200 KwikPen delivers the same dose in half the volume of U-100 mealtime insulin pens, with no dose conversions required, and can be dialed in one-unit increments to a maximum of 60 units per injection.

As with other mealtime insulin pens, Humalog U-200 KwikPen must be used within 28 days after initial use, even if insulin remains. Unused pens should be stored in the refrigerator, but once a pen has been used for the first time, it should be kept at room temperature. Humalog is available by prescription only.

Priced at Walgreens, it was $477.99 for five pens of the U100 with 3ml each for total of 15ml. The new U200 pen was $467.99 for two pens of 3 ml each for 6ml, which comes out about the same price.

Practice Pearls:

  • The insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.
  • When used in a pump, do not mix or dilute Humalog U-100 with any other insulin or liquid. Do not use Humalog U-200 in an insulin pump.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not mix Humalog U-200 with any other insulin.

For more information on Humalog U-200 KwikPen, visit http://Humalog.com/u200.