Kidney Disease Mortality Increased 52%

The rate of kidney disease mortality in the United States has increased by 52% in the past 16 years and continues to be higher in blacks than whites, according to a study. The findings underscore the need for developing additional measures directed at preventing kidney disease, particularly in black communities.

Analysis of Vital Statistics data revealed that the death rate per 100,000 population rose from 10.1% in 1989 to 15.4% in 2005.

Study investigators also reported that the age-adjusted mortality rate was consistently at least twice as high in blacks vs whites in both men (32.6 [95% CI, 27.1 – 38.1] for black men vs 16.5 [95% CI, 15.2 – 17.8] for white men) and women (27.3 [95% CI, 23.3 – 31.3] for black women vs 11.8 [95% CI, 10.9 – 12.7] for white women).

As might be expected, study results also showed that the death rate increased with age, from 1.1 per 100,000 population (95% CI, 0.9 – 1.3) for people younger than 50 years, to 19.0 (95% CI, 17.2 – 20.8) in those aged 50 to 74 years, and to 173.6 (95% CI, 163.5 – 183.7) for those aged 75 years or older.
The increasing kidney disease death rate in Michigan may be explained in part by the increasing prevalence of kidney failure as well as its risk factors, diabetes and hypertension, the authors note.

Interventions aimed at educating black patients about kidney disease and the need for implementing diet and exercise-oriented prevention measures are available in community-based settings such as beauty salons, barber shops, schools, preschools, and Head Start programs.

March 16 issue of the Morbidity and Mortality Weekly Report. MMWR. 2007;56(10):225-227.

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DID YOU KNOW:
Study Reveals “Missing Link” Between Pre-Diabetes & Type 2 Diabetes: New research suggests a “missing link” between the pre-diabetes state and the clinical diagnosis of type 2 diabetes mellitus. Both impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are intermediate states in the transition from normal glucose tolerance (NGT) toT2DM and have been termed as “pre-diabetes”. They are associated with a high risk for progression to T2DM. Hepatic glucose production (HGP) is the principal determinant of fasting plasma glucose (FPG). In the current study, the authors have demonstrated that, in the non-diabetic range, the rise in fasting plasma glucose (FPG) concentration is associated with a mild decrease in hepatic glucose production (HGP) and a marked decrease in the glucose clearance rate. “Pinpointing the missing link is quite important,” Dr. Jani said. “It allows us to identify potential future targets in order to develop effective therapies to prevent the progression from pre-diabetes to type 2 diabetes.” For more information see this week’s Item #13

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