Issue 164 Item 6 Testosterone Inversely Associated With Atherosclerosis in Diabe

New evidence suggests that low concentrations of testosterone are associated with an increased risk of cardiovascular disease in men.

Dr. Michiaki Fukui, of Osaka General Hospital of West Japan Railway Company, Japan, and colleagues measured serum free and total testosterone concentrations in 253 type 2 diabetic men, and determined carotid intima-media thickness (IMT) and plaque score (PS) ultrasonographically, as well as major cardiovascular risk factors, in a subgroup of 154 patients.

Free testosterone concentration was inversely correlated with IMT (p = 0.0103) and with PS (p < 0.001). Patients with concentrations of free testosterone less than 10 pg/mL had significantly greater IMT (1.01 versus 0.91 mm, p = 0.038) and PS (4.4 versus 2.4, p = 0.0003) than those with higher testosterone levels. [
Also, serum free testosterone concentration inversely correlated with age, as well as with age at onset and duration of diabetes, Dr. Fukui and colleagues report.

The investigators found that serum free testosterone correlated with the severity of atherosclerosis regardless of whether the patients had overt cardiovascular disease or not. Diabetes Care 2003;26:1869-1873.

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