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Improved Fat Oxidation Following Exercise and Weight Loss (EX+WL) Predicts Improved Insulin Sensitivity (IS) in Obesity
Decreased IS in skeletal muscle in obesity entails dysregulation of both glucose and fatty acid metabolism, a combination of metabolic impairments characterized as metabolic inflexibility within skeletal muscle.
This study examined whether a EX+WL intervention in obesity, one that generally enhances IS, also mediates improved fasting rates of fat oxidation (FOX).
Obese (BMI>30 kg´m-2) volunteers (9 men and 16 women) without diabetes, aged 39±4.3 years completed a 16 weeks of moderate intensity EX (4-5 sessions/week, 30-50 minutes of walking or stationary cycling), combined with WL (- 500 to1000 kcal/day). Body composition was determined by DXA and CT. IS was measured during euglycemia hyperinsulinemia (40 mU•m-2•min-1), and systemic energy expenditure and substrate oxidation was determined via indirect calorimetry. Fat mass and regional fat depots were significantly reduced, with a mean WL of 9±1%, and VO2max improved by 19%, from 38.8±1.2 to 46.0±1.0 ml´kgFFM-1´min-1 (p<0.05). IS improved 49±10% (6.70 ± 0.40 to 9.51 ± 0.51 mg•min-1•kg FFM-1; p<0.05). Rates of FOX following an overnight fast increased (1.16 ± 0.06 to 1.36 ± 0.05 mg•min-1•kg FFM-1; p<0.05), and the proportion of energy derived from FOX increased from 38% to 52%. In a multivariate examination of factors associated with improved IS, including changes in adiposity and fitness, the strongest predictor was enhanced fasting rates of FOX, accounting for 52% of the variance in improvement of IS.
From the Results of the study it was conculed that, in obesity, EX+WL substantially enhances IS and increases post-absorptive FOX, and this restoration of metabolic flexibility in skeletal muscle is a key predictor of the improvement in IS.
[1010-P] Improved Fat Oxidation Following Exercise and Weight Loss (EX+WL) Predicts Improved Insulin Sensitivity (IS) in Obesity BRET H. GOODPASTER, CAROL A. KELLEY, ANDREAS KATSIARAS, DAVID E. KELLEY. Pittsburgh, PA.
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