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Heart Failure in T2DM: Ready for Prime Time?

Nov 24, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Louise Brown, PharmD Candidate, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences

Although not the most prevalent comorbid condition in patients with T2DM, heart failure was the most fatal in a 17-year long nationwide real-life cohort study. 

The risk of developing heart failure (HF) in patients with T2DM is double for men and triple for women compared to patients without T2DM.  In 2008, the FDA introduced new guidelines that required cardiovascular (CV) safety studies for T2DM medications. Major atherosclerotic coronary events were the primary focus of these studies. It is noteworthy that structural heart disease, including HF, was not included as a primary outcome in these guidelines. Although still not an original primary endpoint, reducing HF hospitalizations is now recognized as an essential safety outcome in diabetes trials....


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