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Gestational Diabetes Can Increase CVD Risk

Jul 27, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Shalonda Kimble, PharmD Candidate, South College School of Pharmacy; Oluwatayo Ishola, PharmD. Candidate, South College, School of Pharmacy; Macrina Ghali, PharmD Candidate 2021, Florida A&M University, College of Pharmacy and Pharmaceutical Sciences

GD history is linked with coronary artery calcification (CAC) in women, an indicator of atherosclerotic CVD, and a predictor of CVD clinical events. 

Gestational diabetes (GD) is a significant risk factor for cardiovascular disease, leading to early-onset and an increased risk of type 2 diabetes. It is unknown whether achieving normoglycemia will mitigate the excess risk of CVD associated with GD history. This study aimed to assess GD history related to coronary artery calcification (CAC) in women. Confirmation is unclear about whether GD history increases CVD risk separate from T2D diagnosis. Although it may seem that maintaining normoglycemic levels reduces CVD risk, women with a history of GD who did not advance to T2D had a 30% to 56% higher CVD risk based on a pooled risk estimate from a meta-analysis. According to previous studies, the risk is still present regardless of glycemic levels post-pregnancy. This analysis evaluated GD history's relationship across the reproductive years to the presence of coronary artery calcium in women during midlife, a strong predictor of atherosclerotic CVD (ASCVD)....


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