Diabetes In Control. A free weekly diabetes newsletter for Medical Professionals. News and information for Medical Professionals.
Fenofibrate treatment for at least 3 years is effective in reducing the progression of renal disease in people with type 2 diabetes.
The lipid improvements seen with fenofibrate therapy are associated with reduced progression to microalbuminuria in patients with type 2 diabetes.
Still, further studies are needed to determine exactly why a lipid-lowering drug would produce this benefit as well as the long-term effects on renal function, lead author Dr. Jean-Claude Ansquer, from Fournier Pharma in Daix, France, and colleagues note.
In the Diabetes Atherosclerosis Intervention Study (DAIS), treatment with fenofibrate improved the lipid profiles of patients with type 2 diabetes and slowed progression of coronary artery disease. In the present analysis of DAIS data, the authors looked at the effect of fenofibrate on changes in urinary albumin excretion in 314 patients.
During the 3-year study, worsening albumin excretion was noted in 18% of patients given placebo compared with just 8% of fenofibrate-treated subjects (p < 0.05). Further analysis showed that this was primarily due to preventing patients with normal albumin excretion from developing microalbuminuria (p < 0.001) rather than from preventing worsening excretion once microalbuminuria is already present.
On multivariate analysis, changes in albumin excretion were independent of age or changes in blood pressure, lipid or creatinine levels, or weight, the investigators point out.
"The present study shows that fenofibrate treatment for at least 3 years is effective in reducing the progression of renal disease in people with type 2 diabetes without diabetic nephropathy," the authors conclude.
Am J Kidney Dis 2005;45:485-493.
=============================
WarmFeet Kit can help with painful neuropathy and wound healing.
To Find our more:
https://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=2007
The 10,000 STEP STUDY:
"The Results". A simple answer to a difficult problem.
https://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=2001