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Doubling the Dose of Semaglutide for Weight Loss Approved

Jun 12, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Laura Martínez López, PharmD. Candidate 2021, Lake Erie College of Osteopathic Medicine, College of Pharmacy

Doubling the Dose of Semaglutide for Weight Loss Approved 

The new approval of Wegovy is for a current medication, semaglutide, but more than doubling the standard dose for diabetes treatment. 


The US Food and Drug Administration (FDA) recently approved a 2.4 mg/week subcutaneous dose of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide (Novo Nordisk) for weight loss. Specifically, this drug format and dosage are approved as an adjunct to a reduced-calorie diet and increased physical activity to treat adults who have obesity (body mass index [BMI] ≥ 30 kg/m2) or are overweight (BMI ≥ 27 kg/m2) with at least one weight-related comorbidity. The approval comes after the results of four 68-week trials of subcutaneous semaglutide 2.4 mg/week versus placebo, which looked at the effects of the 2.4mg dose in patients with overweight or obesity, with and without type 2 diabetes 

STEP-2 examined the effect of the doubled semaglutide dose on patients who had type 2 diabetes as well as overweight/obesity....

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