Sulfonylurea

GLP-1 analog also showed reduction in weight and incidence of hypoglycemia… Dulaglutide (Trulicity) is a glucagon-like peptide analog that is used once weekly to improve blood glucose level. During the open-label, multinational, parallel arm study, researchers compared the safety and efficacy of dulaglutide 0.75mg and 1.5mg to insulin glargine in …

Program helps aid primary care physicians in the management of patients with diabetes using individualized therapy…. A meta-analysis showed that the most efficacious strategies to improve glucose control were: case management, health care team changes, patient education, and facilitated transmission of patient data to clinicians. Using those 4 key strategies …

Device implantation could be the future in T2DM and weight loss… Weight gain is often a side effect of several different oral antidiabetic drugs (OADs), such as sulfonylureas and thiazolidinedion, along with insulin. Lifestyle modification and weight loss is always recommended in T2DM, but we all know it takes great …

Older veterans with T2DM and dementia may need to decrease intensity of diabetes medications… One study predicts that the prevalence of diabetes among adults aged ≥65 years is projected to increase dramatically by 2050. Other studies have observed that dementia affects up to 16% of diabetic patients aged ≥65 years …

Addition of dapagliflozin may benefit patients whose blood glucose is uncontrolled with both metformin and sulfonylurea… Dapagliflozin is a selective and reversible sodium-glucose co-transporter 2 (SGLT2) inhibitor, which lowers plasma glucose level by increasing urinary excretion of glucose. Addition of dapagliflozin may benefit patients whose blood glucose is uncontrolled with …

David Levy, MD, FRCP Drugs acting on the incretin system (entero-insular axis) (Fig. 6.2) The incretin effect Bayliss and Starling inferred the existence of gut-derived substances affecting carbohydrate metabolism more than a century ago, but the incretin effect was not described until 1969: the observation that for a given achieved level …

From our publisher, Steve Freed, comes this thought-provoking discussion of how better diabetes control can impact cost, quality of life and mortality…

Initial combination therapy of metformin, pioglitazone, and exenatide might be more effective in reducing HbA1c compared to sequential add-on in new-onset diabetic patients… The purpose of this study is to initiate a therapy regimen that will reduce HbA1c, increase insulin secretion, and increase insulin sensitivity. This therapy will also avoid …

David Levy, MD, FRCP Introduction The pharmacological management of blood glucose in type 2 diabetes remains the most contentious area of diabetes management, and although until relatively recently in the USA the only agents to treat blood glucose were insulin and sulphonylureas, this limited repertoire in no way inhibited the controversy, …

The Endocrine Society has released a clinical practice guideline on the pharmacological management of obesity that includes recommendations on strategies for prescribing weight loss drugs.