DPP-4 Therapy Center

SAVOR (Saxagliptin Assessment of Vascular Outcomes Recorded in patients with diabetes mellitus) trial showed a 27% increase in hospitalizations for heart failure among patients receiving saxagliptin as opposed to placebo….

In this special Homerun Slides presentation, details of the CANTATA-D2 study are reviewed comparing the effects and benefits of the SGLT2 inhibitors and DPP-4 inhibitors…. To download in PowerPoint (.ppt) format: SGLT2 Inhibitors for Treatment of Type 2 Diabetes See more SGLT-2 Resources

David Joffe, BSPharm, CDE  Brittany Davis, Pharm D Candidate, Presbyterian College School of Pharmacy The molecular mechanisms linking fatty acids to GLP-1 secretion from gut endocrine cells remain incompletely understood. Hirasawa and colleagues have identified a GPCR, designated GPR120 that serves as a receptor for fatty acids on gut endocrine cells. …

Ivy, a 29-year-old woman, presents with a short history of polyuria and polydipsia. What differential diagnosis would you be thinking of? The differential diagnosis includes: • Diabetes mellitus • Hypercalcaemia • Chronic renal failure • Diabetes insipidus • Psychogenic polydipsia

Post market study results…. 

Tolerability in type 2 diabetes patients aged 65 years and older…. 

New research assesses safety and efficacy of linagliptin as add on treatment in elderly diabetes patients….

Scientific understanding of the disease shifts treatment to drugs with newer mechanisms…. 

About 50% of patients experience the dawn phenomenon…. 

In earlier clinical trials dapagliflozin consistently reduced HbA1c in treatment-naive patients….