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CLA supplementation significantly increased fasting glucose concentrations (6.3%) and reduced insulin sensitivity. There is quite a bit of publicity on the use of CLA for weight loss. This is of interest to overweight or obese type 2 patients. Some animal studies have suggested that (CLA) supplementation may have therapeutic potential with respect to insulin sensitivity and lipid metabolism.
Researchers at the Department of Clinical Medicine, Trinity Centre for Health Sciences, and the Metabolic Research Unit, St James’s Hospital, both in Dublin, investigated the effect of CLA supplementation on markers of glucose and insulin metabolism, lipoprotein metabolism, and inflammatory markers of CVD in subjects with type 2 diabetes.
Thirty-two subjects with stable, diet-controlled type 2 diabetes received CLA in a randomized, double-blind, placebo-controlled trial. A 3-h 75-g oral-glucose-tolerance test was performed, and fasting plasma lipid concentrations and inflammatory markers were measured before and after the intervention.
Much to the researchers surprise the CLA supplementation significantly increased fasting glucose concentrations (6.3%) and reduced insulin sensitivity. Total HDL-cholesterol concentrations increased by 8%, The ratio of LDL to HDL cholesterol was significantly reduced. CLA supplementation reduced fibrinogen concentrations, but had no effect on the inflammatory markers of CVD (C-reactive protein and interleukin 6). Based on this small study it would be hard to recommend a nutrient with potentially adverse effects on type 2 diabetes patients.
American Journal of Clinical Nutrition, Vol. 80, No. 4, 887-895, October 2004
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