What happens when a medication that quietly supports weight loss and glucose control suddenly disappears? For many patients, an unexpected break in GLP-1 therapy feels like pulling the rug out from under hard-earned progress. Supply shortages, insurance denials, side effects, or planned drug holidays are now common reasons people stop …
Read More »Talking About Off‑Label GLP‑1 Use: How to Answer Patients Without Overpromising
A patient walks into your exam room, hopeful after reading that a diabetes drug might help with memory loss, addiction, or even anxiety. You know they’re talking about GLP‑1s—but how do you respond when the science is still unfolding? As GLP‑1 receptor agonists capture public attention for much more than …
Read More »GLP‑1 Stewardship in the Clinic: Prioritizing, Deprescribing, and Switching Without Chaos
What happens when a breakthrough therapy becomes too popular for its own good? Clinics across the country are struggling to manage demand for GLP‑1 receptor agonists amid soaring prescriptions, medication shortages, and shifting insurance coverage. Without a strategy, patients fall through the cracks—and providers are left making chaotic case-by-case decisions. …
Read More »GLP‑1s on the WHO Radar: Turning Global Guidance Into Everyday Prescribing
What happens when a once-costly, class-specific treatment becomes a global health priority? That’s the question raised by the World Health Organization’s latest move: recognizing GLP‑1 receptor agonists as essential medicines and issuing new recommendations for their use in obesity and diabetes care. These updated GLP‑1 WHO guidelines are more than …
Read More »Aiming for MASH Resolution: How to Use GLP‑1s in Liver‑First Diabetes Care
What if the key to resolving both diabetes and liver disease lies in a single therapeutic approach? As rates of metabolic dysfunction-associated steatohepatitis (MASH) rise among people with type 2 diabetes, many clinicians are rethinking how they prioritize treatment. Rather than treating glucose and liver health in silos, combining therapies …
Read More »GLP‑1s in Type 1 Diabetes With Obesity: When Do the 2026 Rules Say “Yes”?
Imagine managing type 1 diabetes and still gaining weight despite careful insulin use, exercise, and carb counting. That’s the frustrating reality for many people living with T1D and obesity. While insulin is life-saving, it can also promote weight gain, making the balance between glucose control and healthy weight even harder. …
Read More »GLP‑1s in Menopause: Using Incretins to Protect Cardiometabolic Health in Midlife
Menopause marks a major transition in a woman’s life, defined not only by the end of menstrual cycles but also by profound hormonal and metabolic changes. One often under‑recognized shift is the acceleration of cardiometabolic risk. Women in midlife frequently experience increased central adiposity, changes in glucose regulation, rising blood …
Read More »GLP‑1s and Liver Disease: Rethinking MASLD Care Beyond Obesity and A1C
Nonalcoholic steatohepatitis (NASH) and metabolic dysfunction–associated steatotic liver disease (MASLD) are rapidly becoming leading causes of chronic liver disease worldwide. Traditionally, clinicians have associated MASLD with obesity, insulin resistance, and type 2 diabetes, often using body mass index (BMI) and A1C as screening triggers. However, an important shift is occurring …
Read More »Prescribing GLP‑1s for Obesity Without Diabetes: How to Treat “Normoglycemic” Risk
In recent years, GLP‑1-based treatments for obesity have evolved from being primarily a diabetes-focused strategy to becoming a powerful tool for managing weight and reducing cardiometabolic risk—especially in individuals without type 2 diabetes. This growing trend is shifting how clinicians identify and manage obesity, moving beyond A1C levels to a …
Read More »GLP‑1s for PCOS: From Insulin Resistance to Cycle Control
Could a diabetes medication help women with PCOS regain control of their cycles and metabolism? GLP‑1 receptor agonists, best known for treating type 2 diabetes and obesity, are showing promise for women with polycystic ovary syndrome (PCOS). These medications may support weight loss, improve insulin resistance, and even lead to …
Read More »
Diabetes In Control. A free weekly diabetes newsletter for Medical Professionals. News and information for Medical Professionals.