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CLINICAL CASE VIGNETTE: Treating Weight Concerns

Jun 9, 2018

After four years of good glycemic control with metformin 1500 mg a day, Mrs. Hunter returns for her 6-month follow-up visit. At this time, her office A1C is 8.2% and she has gained seven pounds. She is very concerned about her weight gain. If weight is a concern, what would be the best antiglycemic drug to add to her regimen?


Answer: D. A GLP-1 receptor agonist

Educational Critique: The use of GLP-1 receptor agonists is associated with modest-significant weight reduction. The other medications listed are either associated with weight gain or are weight neutral.