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Cause-Specific Mortality Due to Hypoglycemia

Jan 19, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Shana Indawala, PharmD Candidate, University of South Florida Health, Taneja College of Pharmacy

A retrospective observational study on hypoglycemia and mortality seeks to determine absolute risk of death due to CVD, cancer, and other causes in patients who experienced a severe hypoglycemic event. 

While it is recognized that severe hypoglycemia can lead to fatal complications, such as arrhythmias, seizures, and coma, the long-term profile of severe hypoglycemia is unknown. The 2008 Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial showed that there was lower risk of death due to severe hypoglycemia in patients receiving intensive control than in conventional treatment patients. However, the Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) trial showcased that patients with hypoglycemic events requiring medical assistance also had increased risk of developing cancer and skin, respiratory, and digestive complications. Thus, this study seeks to assess the long-term risk of CVD and non-CVD deaths associated with hypoglycemia....


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