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Canagliflozin Linked to Improved Anemia in Patients with Diabetes and Renal Disease

Mar 27, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Adrian Gavre, PharmD Candidate, Philadelphia College of Osteopathic Medicine

SGLT-2 inhibitors show additional benefits besides lowering blood glucose.

SGLT-2 inhibitors such as canagliflozin are shown to be beneficial to patients who have both type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) in regards to developing anemia. Canagliflozin targets sodium-glucose cotransporter 2 within renal cells, resulting in increased excretion of glucose through the urine and decreasing glucose reabsorption rates of filtered glucose.


According to a recent post-hoc analysis of the CREDENCE trial (Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation), there was a statistically significant difference in the risk of developing anemia and other anemia events between the placebo and canagliflozin group....


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