Use of the Anodyne Therapy System (ATS) appears to elevate NO locally so that blood flow can be increased directly at the site of application. This increase in blood flow is the basis of the therapeutic benefits of the ATS on pain and neuropathy, as we discussed earlier. Recall that arterial AND venous dilation occur …

Diabetic patients, their physicians and health care providers, including certified diabetic educators, all recognize that diabetes is a disease in which blood flow slowly and insidiously decreases over time. The heart, kidneys, eyes, skin, and nerves all exhibit signs of reduced blood flow. One organ may show symptoms earlier than another, …

In previous articles we have alluded to the positive effects of NO on wound healing. In this article we address the overall implication of NO in wound prevention and wound healing.     Thomas Burke, Ph.D. In previous articles we have alluded to the positive effects of NO on wound healing. In this …

Light-mediated vasodilation was first described by R. F. Furchgott, in his nitric oxide research that led to his receipt of a Nobel Prize in 1998. Later studies conducted by other researchers confirm and extend Furchgott’s early work and demonstrate the ability of light or photo energy to influence the localized …

Diabetic Peripheral Neuropathy (DPN: peripheral nerve damage) is a common complication of diabetes. Almost 70% of people with diabetes develop DPN within five years and after five, years the incidence rate increases to almost 100%. DPN most often begins as a tingling feeling and insidiously progresses to loss of sensation …

Nitric Oxide (NO) offers pain relief in a number of ways. In fact, NO is the mediator of the analgesic effect of opioids such as morphine. In this article we describe how NO affects pain responses and, in particular, certain pain responses in people with diabetes. Thomas Burke, Ph.D. Nitric …

Nitric Oxide (NO) and its interrelationship with essential growth factors is critically involved in the entire continuum of events associated with wound repair, including cell division, maturation, neovascularization, and collagen synthesis including proper cross-linking of collagen fibers.     Thomas Burke, Ph.D. Nitric Oxide (NO) and its interrelationship with essential growth …

Diabetic patients are particularly at risk for damage to sensory and motor nerves in the feet or to dysfunction of the autonomic nervous system that innervates internal organs, for example, the intestine. The clinical diagnosis of the latter condition is gastroparesis. NO is an important signaling molecule conveying information from …

NO initiates and maintains vasodilation through a cascade of biological events that culminate in the relaxation of smooth muscle cells that line arteries, veins, lymphatics. While somewhat complex, the sequence of biological events that are triggered by NO is described below:  Thomas Burke, Ph.D.   NO initiates and maintains vasodilation through …

To understand NO metabolism in diabetic patients we must first discuss the normal process of NO formation. NO is a gas that is also a short-lived, unstable free radical and, within seconds of production, must become stabilized. To do so, it reacts with one or more elements or biologic compounds, as …