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Diabetes In Control

Cyrus Desouza, MBBS, Introduction

Dr. Cyrus Desouza, MBBS, tells us a little about himself and talks about his work investigating the relationship between cardiovascular disease and diabetes. He is particularly interested in how diabetes drugs affect the cardiovascular system.

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Cyrus Desouza, MBBS, Q1: Cardiovascular Benefits of SGLT2s, GLP-1s, and DPP-4s?

Dr. Cyrus Desouza, MBBS, talks about the cardiovascular side effects of newer classes of drugs. SGLT2 inhibitors are still relatively new so there is not much information but they do show some weight loss effects, seem to lower blood pressure, and may have some CV benefits. However, we don’t know what they …

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Cyrus Desouza, MBBS: Status of TZD’s including Avandia

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Dr. Cyrus Desouza, MBBS, addresses the controversy around TZD’s especially Avandia. He notes that the initial research in animal models seemed to preserve beta function, raised adiponectin levels, improved endothelial function,and showed beneficial effects on BP. Hoever, with pioglitazone, a debate began on whether they were protective or not because of a retrospective study. …

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Cyrus Desouza, MBBS, Q3: Pros and Cons of Prescribing Actos

Dr. Cyrus Desouza, MBBS, discusses why he prescribes Actos, a thiazolidinedione. But he says there are some issues with this kind of drug, particularly weight gain. He does not prescribe actos to patients with high BMI’s and is also cautious because of bladder cancer concerns. Many patients are aware of these issues …

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