Combining SGLT2 inhibitor treatment with strategies to maintain energy intake or curb appetite could be an avenue for weight loss….

Early probiotic supplementation may reduce the risk of islet autoimmunity in young children…. Gut microbiota play an important role in enhancing immune system and excluding pathogens competition. Previous studies have shown that dysbiosis in gut microbiota and impaired gut barrier could be associated with type 1 diabetes in humans and …

Researchers are unsure why the phenotype is increasing but suggest that more effective treatments may be contributing to the increase in non-albuminuric CKD…. Chronic kidney disease (CKD) is a common complication of diabetes associated with glomerular filtration rate (GFR) loss. Normally, before the GFR loss occurs, albuminuria will be detected. …

Higher levels of hypothalamic nitric oxide could lead to less insulin clearance and more lipogenesis…. Nitric oxide (NO) is an important neurotransmitter produced in the paraventricular nucleus (PVN) of the hypothalamus. Previous studies suggested that the level of NO was inversely correlated with systemic insulin clearance. However, little is known …

Patients with diabetic peripheral neuropathy (DPN) are more likely to experience a fall during stair walking….  Diabetic peripheral neuropathy has been shown in previous studies to cause postural sway during standing and walking on level ground in diabetic patients but no data is available regarding the effect of DPN on …

Long-term mortality of patients with ischemic heart disease is independently predicted by diabetes…. Anna Norhammar, MD, PhD, of the cardiology unit in the department of medicine at Karolinska Institutet in Sweden, said during her presentation, “Diabetes is common among patients with heart failure that report ischemic heart disease and it’s …

“An interaction of genetic risk with physical activity on incident type 2 diabetes that appears to be driven principally through genetic risk to insulin resistance.”…  Yann C. Klimentidis, PhD, of the University of Arizona Mel and Enid Zuckerman College of Public Health in Tucson, and colleagues wrote, “It has been …

Besides sulfonylureas, GLP-1RA can also be a treatment option for HNF1A diabetic patients…. Maturity-onset diabetes of the young adults (MODY) is responsible for 1-2% of all cases of diabetes. HNF1A diabetes is caused by loss of B-cell functions. It is usually misclassified as type 1 diabetes due to common hyperglycemic …

No effect of tight glycemic control on mortality or major cardiovascular events in long-term follow-up of the ADVANCE trial….  The Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE study) assessed the effects of routine blood-pressure lowering and strict glucose control in a broad cross …

Promising trial showed safe restoration of near-normoglycemia in type 1 diabetes…. Islet transplantation is a well-established therapeutic treatment for a subset of patients with difficult to control type 1 diabetes mellitus. Before the Edmonton Protocol, only 9% of the 267 islet transplant recipients since 1999 were insulin independent for more …