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Adding Basal Insulin Analogue Detemir

Feb 3, 2018

A 59-year-old patient who was diagnosed with type 2 diabetes five years ago presents to your clinic for an appointment. He has a history of hypertension and dyslipidemia, both currently well-controlled with medication. He has been taking metformin and a DPP-4 inhibitor. He tells you he is concerned about a sore on his foot that is taking a long time to heal. At today’s visit, his office A1C is 8.8%. After discussing his options, you decide to add basal insulin analogue detemir to his regimen. Compared to insulin NPH, what would you expect him to experience while taking detemir?


Correct Answer:  A. Less weight gain

Educational Critique: Compared to NPH, the use of long-acting insulin analogues (glargine and detemir) have been associated with modestly less weight gain and overnight hypoglycemia.


Diabetes, Obesity and Metabolism, 11, 2009, 372–378