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ADA 2021: Genetic Risk Score for Type 2 Diabetes and Traits Related to Glucose

Jul 20, 2021
 
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Torré Anderson, II, Fourth Year Doctor of Pharmacy Candidate, Florida A&M University College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health 

Genetic risk scores can help provide insight into the problem of increasing youth-onset type 2 diabetes rates.  

Type 2 diabetes is a condition that accounts for 20-50% of new cases of diabetes among the youth in the United States. Disease prevalence projections estimate a four-fold increase in youth populations by the year 2050. Youth-onset of type 2 diabetes is very distinct as compared to adult-onset. Youth-onset is associated with obesity, higher incidence of complications, aggressive progression of the disease, and reduced response to treatment. The prevalence among youth in all ethnicities is increasing, but in non-Hispanic black youth is growing much faster. Genomic-wide association studies (GWAS) have recognized over 300 single nucleotide polymorphisms (SNPs) correlating to type 2 diabetes. Understanding risk factors and the rate progression of disease-associated to them would be essential in managing type 2 diabetes....

 

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