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ADA 2021: A Promising Future for Tirzepatide

Jul 17, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Jasmine Dumontier-Hiott, PharmD Candidate 2022, University of South Florida Taneja College of Pharmacy 

American Diabetes Association symposium presents new phase 3 clinical trials of SURPASS-3 and SURPASS-5. 

Tirzepatide is a once-weekly injectable medication for patients with type 2 diabetes who may not have achieved optimal therapeutic outcomes while taking oral antihyperglycemic medications. The novel dual GIP-GLP-1 agonist tirzepatide has demonstrated remarkable findings in the SURPASS-1 and SURPASS-2 phase 3 clinical trials. The SURPASS-1 trial of tirzepatide versus placebo concluded a significant HbA1C reduction below 5.7% in 31-52% of participants in the tirzepatide groups. The SURPASS-2 trial of tirzepatide versus semaglutide as an add-on to metformin established a substantial HbA1C reduction below 5.7% was achieved by 29-51% of the tirzepatide participants. Additional phase 3 trials further investigated whether the significant improvements in glycemic control continue compared to guideline-recommended treatments.  


The SURPASS-3 is a randomized, open-label trial comparing the effect of tirzepatide versus titrated insulin degludec on glycemic control in patients with type 2 diabetes as an add-on to metformin....

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