ACE Inhibitors and ARB’s are Heart Savers for Diabetes Patients

Therapy emerges as a critical therapeutic intervention

With diabetes mellitus reaching epidemic proportions, mainly secondary to obesity, the impact of cardiovascular disease due to this combination makes it a dominant public health problem during the first quarter of the 21st century.

The complex interaction that results in diabetic heart disease is created by overlapping mechanisms. There is a propensity to develop premature, diffuse atherosclerotic coronary disease, which is associated with adverse short- and long-term morbidity and mortality. There are structural and functional abnormalities of the microvasculature, autonomic dysfunction, and intrinsic failure of myocardial contraction (so-called diabetic cardiomyopathy). These changes are amplified by arterial hypertension and kidney disease. The role of the renin-angiotensin-aldosterone system is a crucial driver of most of the pathophysiologic mechanisms behind diabetic heart disease and why in the past 5 years blocking this system in diabetic patients has emerged as a critical therapeutic intervention.

Arch Intern Med. 2004;164:1737-1748.
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DID YOU KNOW: While an estimated 17 million Americans are living with diabetes, about 41 million Americans fall into the pre-diabetes category, which means that they have blood sugar levels that are higher than normal but not at a diabetic level.