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A1C as a Predictor of Mortality in Patients with Diabetes

Aug 31, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Jerrine Fletcher, Fourth Year Doctor of Pharmacy Candidate, Florida A&M University College of Pharmacy

Can variability in HbA1c lead to a higher risk of mortality in persons with diabetes?

A study published in the Diabetes/Metabolism Research and Review journal indicated an increased risk of mortality in adult patients with variability in HbA1c levels over five years. Previous studies have established a relationship between HbA1C and diabetic complications. Variability in HbA1c levels has been linked to higher rates of adverse outcomes. These adverse outcomes include cognitive decline, amputations, microvascular and macrovascular complications. Data analyzed from about 300,000 adults with diabetes showed that HbA1c trends could be a predictor of mortality. A greater risk of death was observed in all adults with a decreasing HbA1c trend. Patients with diabetes 70 years and older have a higher mortality risk with an increasing HbA1c trend. Patients who maintain a stable HbA1c level are at a lower risk of mortality than patients with varying HbA1c....


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