July 17, 2021 : Issue #1150

TOP STORIES — Diabetes News and Research: ADA 2021

A Promising Future for Tirzepatide

Long-term Safety of Intranasal Insulin in Insulin-Dependent Type 2 Diabetes

For Athletes To Optimize Their Performance and Glycemia, Should They Cut Carbs or Carb Load?
with exclusive commentary from Sheri Colberg, PhD

Ashley Ball, PharmD Candidate, LECOM-School of Pharmacy, put together a great article on the comparative benefits of low carb vs. high carb intake to maximize athletic performance. She brings to the forefront the need to individualize a food plan based on the activity and duration. What is very interesting is how this information can be used with our diabetes patients to improve outcomes for them as well.

I know we have probably had 100 or more articles on these topics, and the results seem to be all over the place. I shared this article with Dr. Sheri Colberg, and her analysis is right below the article.

I am going to try some of the recommendations this weekend while cycling and will give my impressions next week. I might even close both my eyes so it can be a “double blinded” study.

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We can make a difference!

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Dave Joffe

Editor-in-chief

American Diabetes Association symposium presents new phase 3 clinical trials of SURPASS-3 and SURPASS-5. 

Researchers assess the safety of intranasal insulin as a treatment for type 2 diabetes-associated cognitive impairment in aging adult populations. 

The internet has many different opinions of what an optimal diet is for athletes, but what do the experts say?

With exclusive commentary from Sheri Colberg, PhD.

This study explored the effect of almond consumption on determinants of metabolic dysfunction—blood glucose, lipids, insulin, and selected inflammatory markers—in adolescents and young adults aged 16–25 years. This randomized controlled trial was conducted for 90 days on individuals with impaired levels of fasting glucose: between 100–125 mg/dL (5.6–6.9 mmol/L) and 2-h post-glucose value 140–199 mg/dL (7.8–11.0 mmol/L), and fasting insulin (≥15 mIU/ml)/stimulated insulin (≥80 mIU/ml). Of 1,313 individuals screened, 421 met the inclusion criteria, of which 275 consented to participate, and 219 completed the trial. Participants in the almonds group received 56 g of raw almonds daily (providing ~20% of the daily energy intake, i.e., 340 kcals/d), distributed in 2 packets that were to be consumed as snacks.

The study, published in the journal Frontiers in Nutrition, found that snacking on 56 grams of almonds every day for 12 weeks significantly reduced mean A1C and total cholesterol, low-density lipoprotein cholesterol, and inflammatory marker IL-6 compared with eating regular Indian savory snacks. The mean glycosylated hemoglobin levels (HbA1c) levels showed a significant reduction in the almond group compared to the control group. In addition, there was a decrease in the fasting blood glucose to fasting insulin ratio (FG: FI) in the almond group compared to the control group. Thus, most of the participants in the present study did not have either impaired fasting or high postprandial glucose levels and were included in the study as they were found to be insulin resistant. This may be regarded as one of the strengths of the present study, where participants were studied at an earlier stage of disturbance in metabolic health, much before blood glucose levels became elevated.

The researchers wrote that “almonds can be a good [healthful] snack that can replace regular snacks and can be considered as a part of the food-based strategy to help prevent prediabetes, especially in the young.” Front. Nutr., June 24, 2021

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters:

Torré Anderson, II, Fourth Year Doctor of Pharmacy Candidate, Florida A&M University College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health

Ashley Ball, PharmD Candidate, LECOM-School of Pharmacy

Jasmine Dumontier-Hiott, PharmD Candidate 2022, University of South Florida Taneja College of Pharmacy

Alan Martinez, PharmD Candidate, University of South Florida Taneja College of Pharmacy 

Your Friends in Diabetes Care
Steve and Dave

Diabetes In Control
www.diabetesincontrol.com