September 25, 2018 : DCMS #416

DISASTERS AVERTED — Near Miss Case Studies

PCOS Can Be a Family Matter

EXCLUSIVE INTERVIEW — Candid Video Interviews with Top Practitioners

Rhoda H. Cobin on PCOS and Diabetes

HOMERUN SLIDES — Great Clinical Presentation Highlights

Practical Use of CGM To Improve Clinical Outcomes Part 2

CLINICAL GEMS — The Best from Diabetes Texts

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #144: The Genetics of Type 2 Diabetes Part 6

MOST POPULAR ARTICLES OF THE MONTH

#1 When and When Not to Use An SGLT-2
#2 A Major Diabetes Complication That We Fail to Address
#3 Nuts, Nuts, and More Nuts Lower A1c and Cardiovascular Disease

According to medical references, Polycystic Ovary Syndrome (PCOS) is a group of symptoms due to elevated androgens in females. But what does that mean for your patients and their families, and why do we see an increased incidence at younger and younger ages?

At the recent AACE meetings, our medical editor, Joy Pape, sits down with Dr. Rhoda Cobin, Clinical Professor, Mount Sinai Hospital, as she shares her thoughts on how PCOS affects diabetes, what else could be happening in the body, and some of the practices that she employs.

Dave Joffe

Editor-in-chief

When you have female patients who have type 2 diabetes, obesity, a history of irregular periods and/or the other symptoms of PCOS, ask them about their daughters. Do they have like symptoms of PCOS, as Dr. Cobin discusses in her videos?

Rhoda H. Cobin, MD, MACE is Clinical Professor of Medicine at the Ichan School of Medicine at Mount Sinai NYC. She is a founding board member of AACE, served as its president and the president of the American College of Endocrinology. Dr. Cobin’s academic interests include reproductive endocrinology, thyroid disease and thyroid cancer, and diabetes. She was one of the chairs for the production of AACe’s Disease State Clincial Review : Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome. She and AACE have particularly been concerned for over a decade with increasing awareness of the significant cardiometabolic consequences of PCOS.

In this week’s Homerun Slides,  the accuracy of CGMs and the benefit for insulin-using patients.

Gene–gene and gene–environment interactions: Gene–gene interactions, or epistasis, have been suggested as a possible explanation for difficulties in replicating genetic association in complex diseases. The standard statistical methods used in association studies are usually limited to analysis of single marker effects and thereby do not account for interactions between markers. Previous attempts to study epistasis in complex diseases have focused on interactions between candidate regions. However, the recent abundance of GWAS data has made a comprehensive search across the genome more feasible.

After reviewing evidence, a tool to evaluate benefit and risk has been developed for the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors.

Nonadherence to diabetes medications 2nd leading cause of hospitalizations

New study shows that nut intake may improve glycemic control and reduce risk of cardiovascular disease in people who have type 2 diabetes.