Hyperuricemia Associated With Type 2 Diabetes

High serum uric acid level was an independent risk factor for the development of type 2 diabetes in a large population-based study. Among 4,536 people aged 55 years and older in the Rotterdam Study who were free of diabetes at baseline and followed for a mean of 10 years, 462 developed diabetes, for an incidence of 10.1/1,000 person-years. Participants with serum uric acid levels in the top quartile (above 370 micromol/L) were 68% more likely to develop type 2 diabetes than were those in the lowest quartile (267 micromol/L or below), a difference that was significant after adjustment for potential confounders.
“One-quarter of diabetes cases can be attributed to a high serum uric acid level,” reported Dr. Abbas Dehghan and colleagues of Erasmus Medical Center, Rotterdam, the Netherlands

Gout and renal disorders are currently the only confirmed consequences of hyperuricemia, but other studies have implicated high serum uric acid as potential risk factors for hypertension, stroke, and cardiovascular disease. The current study adds type 2 diabetes to the list, the investigators wrote.
Diabetes Care 2008;31:361–2.

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