Type 2 Diabetes: Genes Linked To Insulin Resistance Identified

New research from University of Alabama at Birmingham identifies two genes that may play a role in insulin resistance, opening a new avenue for researchers searching for treatments for type 2 diabetes and metabolic syndrome.

The UAB team found that two genes, NR4A3 and NR4A1, seem to boost insulin sensitivity in muscle tissue.
Insulin lowers blood glucose, or sugar, by moving it from the bloodstream into skeletal muscle, where it is metabolized for energy or stored for later use. Type 2 diabetes results from either a shortage of insulin or from de-sensitized muscle that does not respond well to insulin, allowing elevated glucose levels to remain in the blood stream. This latter defect is called insulin resistance.

“Our findings* show that these two proteins help sensitize muscle to insulin, promoting glucose uptake and thus keeping glucose levels within healthy limits,” said W. Timothy Garvey, M.D., professor and chair of the Department of Nutrition Sciences at UAB and the lead investigator of the study. “This gives science a new target for diabetes research by suggesting new pathways for drug development that will help boost the presence or activity of NR4A3 and NR4A1.”

Garvey and colleague Yuchang Fu, Ph.D., assistant professor of nutrition sciences, also found that both genes were under-expressed in animal models with diabetes, leading to increased insulin resistance.

“In simple terms, the abundant presence of these proteins in the body is a positive factor for avoiding diabetes, while their absence is associated with increased incidence of the disease,” Garvey said. “By better understanding the biologic underpinnings of the disease, we can begin to find novel therapeutic targets to decrease insulin resistance.”

Garvey said the next step will be a methodical search of promising molecules that may interact with and promote the presence of NR4A3 and NR4A1.

There are more than 20 million Americans living with diabetes, 7 percent of the population. According to the National Institutes of Health, the incidence of diabetes is likely to increase due to the aging U.S. population and to the prevalence of obesity in America, both of which are risk factors for diabetes.

According to recent estimates from the Centers for Disease Control and Prevention, diabetes will affect one in three people born in 2000 in the United States. The prevalence of diagnosed diabetes in the United States is expected to increase 165 percent by 2050. Diabetes is widely recognized as one of the leading causes of death and disability in America.

These findings were published recently in the Journal of Biological Chemistry. University of Alabama at Birmingham (2007, October 27). Type 2 Diabetes: Genes Linked To Insulin Resistance Identified.

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DID YOU KNOW:
You can chew gum for gastroparesis: If you suffer from gastroparesis, or delayed stomach emptying, chewing sugar-free gum may help.  Gastroparesis is caused by nerve damage in the gastrointestinal system, and people with the condition suffer from heartburn, bloating, nausea, vomiting, and other gastrointestinal distress. They also frequently experience erratic blood sugar levels as their rate of digestion is unpredictable.  The act of chewing gum produces saliva, which not only contains helpful digestive enzymes but also stimulates muscular activity in the stomach. Chewing gum for at least one hour after meals can be a helpful treatment for gastroparesis in addition to other dietary changes. Tip of the Day courtesy of Dr. Richard Bernstein, author of Dr. Bernstein’s Diabetes Solution.
https://www.diabete911.net/

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