Postprandial Hyperglycemia’s Related To Abnormal Variations In Blood Pressure

The researchers concluded that abnormal variations in blood pressure were associated with postprandial hyperglycemia, but not fasting hyperglycemia. A group of researchers led by Dr Frank Pistrosch of the University Hospital Dresden, Germany, evaluated the relationship between variations in diurnal blood pressure and glucose levels in patients with type 2 diabetes. A total of 107 patients with hypertension and type 2 diabetes underwent 24-hour ambulatory blood pressure monitoring. The researchers also created a diurnal blood glucose profile for each patient based on multiple measurements taken under standardized conditions.

easurements were taken before breakfast, 2 hours after breakfast, before lunch, 2 hours after lunch, before dinner, 2 hours after dinner, at 10:00 p.m., at midnight, and at 3:00 a.m. the following day.

The researchers found that 73% had nocturnal nondipping. Nondippers, compared with dippers, had greater postprandial glucose excursions (59.5 vs 40.7; p=0.02), but similar levels of HbA1c and fasting plasma glucose. Patients with nocturnal nondipping had higher urinary protein excretion and a lower day/night heart rate ratio. Postprandial hyperglycemia was an independent predictor of nocturnal nondipping in a multivariate analysis.

The researchers concluded that abnormal variations in blood pressure were associated with postprandial hyperglycemia, but not fasting hyperglycemia, indicating that treatment for postprandial hyperglycemia may restore blood pressure variations.
American Journal of Hypertension 2007;20:541-5

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FACT: 
Insulin Grown in Plants Relieves Diabetes in Mice, Holds Promise for Humans: Capsules of insulin produced in genetically modified lettuce could hold the key to restoring the body’s ability to produce insulin and help millions of Americans who suffer from insulin-dependent diabetes, according to University of Central Florida biomedical researchers.  Professor Henry Daniell’s research team genetically engineered tobacco plants with the insulin gene and then administered freeze-dried plant cells to five-week-old diabetic mice as a powder for eight weeks. By the end of the study, the diabetic mice had normal blood and urine sugar levels, and their cells were producing normal levels of insulin.

University of Central Florida