Pupil Size Predicts Later Complications for Those with Diabetes

Researchers identified a predictive relationship between small pupil size in adolescents with type 1 diabetes and the presence of microalbuminuria and retinopathy 12 years later. In a new recently published study they found that small pupil size during adolescence may help predict diabetes-related complications later in life, such as retinopathy and microalbuminuria, a marker for both cardiovascular and kidney disease.

Small pupil size has been used to predict mortality in adults with diabetes but has not often been used in adolescents. This study, by researchers in Australia, found that adolescents with type 1 diabetes whose pupils were reduced in size were at higher risk for complications from their disease in their 20s. In particular, they were at greater risk for retinopathy – a progressive eye disease – and microalbuminuria, or the presence of small amounts of albumin in the urine, which indicate cardiovascular and kidney problems.

The researchers recommend further research to determine if improved
glycemic control when pupil abnormalities first appear would improve the condition and lead to fewer complications.

Diabetes Care, Jan, 2007

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