Alternate-day Dosing of Statins in Type 2 Diabetic Patients with Dyslipidemia

Alternate-day dosing of atorvastatin could be an effective and safe alternative to daily-dosing in some type 2 diabetic patients. An analysis was made of the effect of alternateday dosing of atorvastatin and standard once-daily dosing, based on mean low-density lipoprotein (LDL) reduction from baseline in type 2 diabetics.

Forty-four type 2 diabetics were enrolled in the study. In compliance with American Diabetes Association (ADA) and National Cholesterol Education Program Expert Panel (NCEP-III) guidelines, LDL-C<100 mg/dl was chosen as the treatment target. Patients were assigned to 10 mg atorvastatin as an initial dose every day. The atorvastatin dose was doubled every 6 weeks if the patients failed to reach the treatment target. After achieving LDL<100 mg/dl, the patients were assigned to the corresponding atorvastatin dose every other day for 12 weeks.

Thirty-three patients correctly completed the study. LDL-C decreased 39% after the every-day period and 23% after the alternate-day atorvastatin dosing period (p<0.05). The target LDL-C concentration of <100 mg/dl was maintained in 19 patients (57.6%) in the alternate-day period. None of the 33 patients showed elevations in liver enzymes or creatine kinase during the alternate-day dosing period. Alternate-day dosing of atorvastatin could be an effective and safe alternative to daily-dosing in some type 2 diabetic patients.

Acta Diabetol. 2006 Nov;43(3):75-8.

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DID YOU KNOW:
Aerobic vs. Anerobic for Patients with Diabetes: Combining resistance training, such as weight lifting, with aerobic workouts appears to be the most beneficial for type 2 for long-term control of blood sugar control than either form of exercise alone, researchers report. For any type of exercise training lasting 12 weeks or longer, the researchers found, hemoglobin A1C levels fell by 0.8 percent. There was some evidence that combining aerobic exercise with resistance training had more of an effect than either type of exercise alone. Diabetes Care, November 2006.

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