Short-term Admin of Losartan in Patients with Impaired Fasting Glucose Improves

Losartan raised serum levels of free IGF-I, which might contribute to the improvement of insulin resistance associated with losartan treatment.

https://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=4047

Blocking the renin–angiotensin system (RAS) may reduce the risk of developing type-2 diabetes, but data are inconclusive and the mechanisms involved are unclear. RAS and RAS inhibition also influence the IGF-I system, which is important in glucose homeostasis. We investigated the effects of the angiotensin-receptor antagonist, losartan, on insulin resistance and IGF-I levels

In this hypothesis-generating study, five individuals with impaired fasting glucose received 100 mg losartan during 8 weeks. Before and after the treatment period, insulin sensitivity was assessed using the homeostasis model assessment of insulin resistance (HOMA), as well as the 2-h continuous infusion of glucose with model assessment (CIGMA). Furthermore, serum levels of free and total IGF-I, IGF-binding protein-3 (IGFBP-3), lipids and HbAlc were measured.

The results showed that after the treatment period, the HOMA score for insulin resistance had decreased from 5.3 ± 1.1 to 3.7 ± 0.9 (P = 0.004) and the 2-h CIGMA score from 23.4 ± 3.1 to 15.9 ± 2.1 (P = 0.07). The serum levels of free IGF-I had increased from 57 ± 18.8 to 134 ± 31.3 pmol/l (P = 0.04). In terms of percentage, the decrease of HOMA correlated with the increase in free IGF-I levels (Pearson’s correlation coefficient r = –0.8; P = 0.07). A trend in the same direction was observed with 2-h CIGMA. No differences were observed in lipids, total IGF-I, IGFBP-3 or HbAlc.

From the results it was concluded that lLosartan raised serum levels of free IGF-I, which might contribute to the improvement of insulin resistance associated with losartan treatment. These observations, if confirmed in broader studies, will help our understanding of the pathogenesis of type-2 diabetes mellitus, as well as the role of angiotensin-receptor antagonists in its prevention.

European Journal of Endocrinology, Vol 155, Issue 2, 293-296

Raj Shah, et al "Blood Pressure and Lower Limb Function in Older Persons." Journal of Gerontology: Medical Sciences 2006; 61A.

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Early-Onset of Diabetes Associated With Increased Risk of Kidney Disease and Death Before Age 55: Onset of type 2 diabetes before age 20 in a population of American Indians is associated with a substantially increased risk of end-stage kidney disease and death between 25 and 55 years of age. Read and print the full news article at: https://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=4064

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