Issue 202 Item 8 Childhood Vaccines Show No Relationship with Development of Typ

Analysis of all children born in Denmark between 1990 and 2000 shows no causal relation between childhood vaccinations and development of type 1 diabetes. Using data from the Danish Civil Registration System, researchers assessed any association between childhood vaccinations and the development of type 1 diabetes among all children, those with a sibling with type 1 diabetes, and whether a clustering of diabetes cases occurred 2 to 4 years after vaccination.

“We speculated that any association between vaccination and type 1 diabetes would be more pronounced among children who were genetically predisposed to diabetes,” reports Anders Hviid, MS, at Statens Serum Institute, Copenhagen. “Although we found that the risk of type 1 diabetes increased among children who had one or more siblings with diabetes, there was no apparent association between diabetes and vaccination among such children.”

During 4,720,517 person-years of follow up, 681 cases of type 1 diabetes occurred, 26 among children with a sibling with type 1 diabetes.

Analysis of diabetes cases occurring 2 to 4 years after vaccination with any type of vaccine showed no evidence of any clustering of cases. The trend for the number of vaccinations received showed an increase of 1.00 in the rate ratio per vaccination.

“The advantage of our study is that we were able to evaluate the association between childhood vaccinations and type 1 diabetes in a nationwide cohort with longitudinal, individual-level information on vaccinations and type 1 diabetes,” the authors write, adding “We found no support for the existence of a causal relation between type 1 diabetes and childhood vaccination overall or at any time after vaccination.” N Engl J Med 2004;350:1398-404.

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The results of a study published in the April issue of the American Journal of Kidney Diseases suggest that resistance training reduces inflammation and improves nutritional status in patients with moderate chronic kidney disease who follow a low-protein diet.