Glycation End Product Receptors Lowered in Diabetes

Levels of endogenous secretory advanced glycation end product receptors (esRAGE), believed to influence diabetic vascular complications, appear to be considerably reduced in patients with diabetes.

Dr. Naoto Katakami, lead investigator stated that "Circulating esRAGE levels are significantly lower in type 1 diabetic patients compared to non-diabetic subjects and are inversely associated with the severity of some diabetic vascular complications."
Dr. Katakami, of Osaka University Graduate School of Medicine, and colleagues came to this conclusion after examining esRAGE levels in 67 diabetics and 23 controls.

Mean levels were 0.266 ng/mL in diabetics and 0.436 ng/mL in controls and were inversely correlated with HbA1c levels. They were also inversely correlated with carotid intimal-medial thickness.

"These results suggest that diabetic patients with lower circulating esRAGE are more susceptible to diabetic vascular complications," Dr. Katakami said.

Dr. Katakami also noted that in further work to be published in a subsequent issue of Diabetes Care, the findings "indicated that circulating esRAGE levels were inversely correlated with HbA1c levels and serum total cholesterol levels in subjects with type 2 diabetes."

These results, he concluded, "suggest that that circulating esRAGE levels are related with not only glycemic control, but also lipid profiles in type 2 diabetic patients."
Diabetes Care 2005;28:2716-2721.

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FACT:
Aspirin has different effects on cardiovascular morbidity and mortality in women and men. Perhaps not surprisingly, aspirin increases the risk of hemorrhagic stroke in both sexes. However, it appears to reduce risk of ischemic stroke in women while having no effect in men, David L. Brown, MD, chief of the Division of Cardiovascular Medicine at State University of New York, Stony Brook, told attendees of this year’s meeting. AHA 2005 Scientific Sessions: Abstracts 3771, 3772, 3802. Presented Nov. 15, 2005.

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