First Link Found Between Obesity, Inflammation And Vascular Disease

Human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke. Researchers found that aspirin and statin drugs, reduce production of CRP from fat cells

They say the discovery, goes a long way to explain why people who are overweight generally have higher levels of the molecule, known as C-reactive protein (CRP), which is now used diagnostically to predict future cardiovascular events.

"This study is the first to show how body fat participates in the inflammatory process that leads to cardiovascular disease, but also demonstrates that this process can be blocked by drugs now on the market," said study leader Edward T. H. Yeh, M.D.
Adipose tissue (body fat) has been lately regarded as a separate body organ which can produce a number of different biologically active molecules – such as cytokine proteins that are associated with inflammation, and the hormone resistin, which is linked to insulin resistance and the development of type two diabetes.

Even if they are healthy, people with more adipose tissue also tend to have higher levels of CRP. Previous research, however, had only found CRP to be produced in liver tissue, although Yeh, Willerson and Paolo Calabro, M.D., discovered in 2003 that the protein also is manufactured in the walls of blood vessels.

"But that didn’t explain obesity’s connection to high levels of CRP and it also was not clear why CRP is higher in patients who have metabolic disorders," Yeh said. So the research team decided to see whether fat cells themselves can be stimulated by inflammatory cytokines or resistin to produce CRP. To help find out, plastic surgery patients at M. D. Anderson donated adipose tissue that would have been discarded, and the research team then isolated fat cells, cultured them and stimulated them under a number of different conditions. They found the cells produced cytokines that resulted in inflammation and that this process triggered production of high levels of C-reactive proteins.

The researchers also discovered that resistin, the hormone associated with diabetes and insulin resistance, can stimulate production of CRP proteins. "And this is interesting because it is known that resistin is itself produced by fat cells," Yeh said.
"We know that patients with metabolic syndromes have higher levels of CRPs, as well as a higher risk of developing heart disease and stroke, but no one understands why that is," Yeh said. "If fat cells by themselves produce inflammatory signals that trigger cells to produce CRPs, and if CRPs also produce biological effects on vascular walls, that could explain the higher risk of cardiovascular disease."

The investigators then solved the other part of the puzzle – why it is that aspirin, statin drugs and an agent known as troglitazone, used to treat diabetes, can reduce CRP levels. They exposed the cultured fat cells that were producing high levels of CRPs to these drugs, and found production of the proteins declined. "We knew from studying patients that these drugs can reduce C-reactive proteins, but now we have direct proof of their benefit."

Even as the CRP picture becomes clearer, there is still much that is not known, say the researchers, including the reason why fat tissue produces an inflammatory response, and just precisely how CRP participates in that process.

"Inflammation is a very complicated phenomenon, but at least we now have a few more clues as to what it does and how the damage it produces can be prevented," Yeh noted.

Journal of the American College of Cardiology, Sept 2005

================================

FACT:
IT pros at high risk of diabetes: Software engineers and call center employees face a higher risk of diabetes. This is primarily because of their erratic sleep patterns and work style, says a recent study. The study, titled CURES (Chennai Urban Rural Epidemiology Study), says that owing to night shifts and work till late hours, the sleep patterns of young software engineers and call center workers get affected. Such stress, results in the release of hormones like corticosteroids, growth hormone, adrenaline and noradrenaline in excessive amounts, which oppose the action of insulin, causing blood glucose levels to escalate. The study showed that 3 per cent of subjects in the age group of 20-25 have either diabetes or pre-diabetes. This increasing prevalence of diabetes at younger age is being attributed to a combination of genetic and environmental factors.