New Technology Provide A painless Way to Check Blood Glucose Levels

New device developed that could mean the elimination of blood drawing to test for glucose levels.

Two tiny devices recently developed by researchers at the National Nuclear Security Administration’s Sandia National Laboratories could mean the elimination of blood drawing by diabetes patients to test glucose levels or by medical personnel to determine if someone is having a heart attack. Test results would be instantaneous.

The two arrays of micron-sized needles operate similarly by penetrating painlessly into the skin. Arranged in varying numbers on a small patch, the needles can measure molecules inside the body, eliminating the need to withdraw blood from a patient.

One device is ElectroNeedles, micron-sized electrodes capable of measuring molecules such as glucose that can donate or accept electrons (redox behavior). The other is µPosts, micron-sized posts that have the potential of painlessly measuring proteins and other macromolecules, including protein markers released during a heart attack, using optical measurements. The platforms complement each other and together create a diagnostic suite capable of detecting many important biological markers.

"The tiny ElectroNeedles, expected to be constructed of cheap throw-away plastic, would not only make glucose testing simple and painless, but would significantly cut the diagnostics time involved in protein analysis," says Jeb Flemming, Sandia project leader. "Because the analysis is done inside the body, the need to withdraw body fluid is eliminated, and because the needles are so small the measurements are painless."

The team realized that the tips of each of the ElectroNeedles and µPosts could be coated with a biologically active layer capable of measuring concentrations of specific lipids, proteins, antibodies, toxins, viruses, and carbohydrates (such as glucose). Using the ElectroNeedles and rapid electrochemical methods for analysis, a measurement can be made in a few seconds. Likewise, using coated µPosts to capture proteins and other non-redox behaving molecules, optical measurements can potentially be made in less than a half hour.

"Multiple chemical platforms, such as µPosts, will change medical diagnostics by giving the physician a greater understanding of the health of the patient in a shorter amount of time than standard laboratory analysis used today in medicine," Buckley says.

The ElectroNeedles and µPosts can be tailored in size to sample in different portions of the skin. For example, they can be made shorter to measure small-molecular-weight compounds such as glucose in the upper layer of the skin, or they can be made longer to measure larger molecules in the blood, such as Troponin I, a key protein released when a person has a heart attack.

"Today if someone goes to an emergency room with chest pains the doctor assesses the patient’s condition based on their symptoms. In order to accurately diagnose a patient the doctor has to take a blood sample, and wait 6 hours for results.

With a µPost test a doctor would know within a couple of minutes of a patient’s arrival at the emergency room if the patient has elevated Troponin I levels, as most of the diagnostics can take place inside an ambulance during a patient’s trip to the hospital.

https://www.sandia.gov/news-center/news-releases/2005/all/elecneedle.html

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