Peptide Replacement Prevents Painful Diabetic Neuropathy

Findings from a new study suggest that C-peptide replacement may be a useful treatment for painful diabetic neuropathy that occurs under insulin-deficient conditions.

Using a rat model of type 1 diabetes, Dr. Anders A. F. Sima and colleagues, from Wayne State University in Detroit, show that although it has no effect on hyperglycemia, C-peptide replacement prevents progressive thermal hyperalgesia and C-fiber loss.
C-peptide replacement seemed to exert its effects by increasing the availability of nerve growth factor and improving insulin expression. This, in turn, led to a reduction in various nociceptive peptides, such as substance P and calcitonin gene-related peptide.

"From these findings we conclude that replacement of insulinomimetic C-peptide prevents abnormalities of neurotrophins, their receptors, and nociceptive neuropeptides (in this rat model of diabetes), resulting in the prevention of C-fiber pathology and nociceptive sensory nerve dysfunction," the authors state.
Ann Neurol 2004;56:827-835.

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DID YOU KNOW:
Cardiovascular Disease Kills Almost One Million, 84 Percent Senior Citizens. Dec. 31, 2004 – Cardiovascular disease (CVD) – still the nation’s No. 1 killer – claimed 927,448 American lives in 2002 and approximately 84 percent of these deaths were in senior citizens 65 and older, according to the American Heart Association’s Heart Disease and Stroke Statistics – 2005 Update