Liver Tests Required Less Often For Actos or Avandia
Issue 223 Item 2

Liver enzymes no longer recommended every 2 months. The first glitazone, Rezulin, caused serious hepatotoxicity. Due to this scare, liver enzymes were recommended every 2 months for the first year for Actos and Avandia.

But they don’t have the side chain suspected to cause liver toxicity…and now with years of experience they appear much safer. The new schedule recommends testing liver enzymes prior to starting therapy…and periodically thereafter.

Recommend discontinuing Actos or Avandia if liver enzymes rise to greater than 3 times normal…or if jaundice occurs. Hosp Pharm 2001;36(4):456-62.

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