Type 2 and Diagnosis BMI, U-Shaped Correlation

Research finds that there is a U-shaped correlation between BMI at time of type 2 diagnosis….

Jennifer Logue, M.D., of the University of Glasgow in the United Kingdom, and colleagues used data from 106,640 patients diagnosed with T2DM in Scotland to investigate the correlation between BMI around the time of diagnosis and mortality. Patients were followed for a mean of 4.7 years to death or the end of 2007.

The highest mortality risk was found for patients with a BMI of 20-25 and greater than 35. Increases in BMI greater than 30 lead to increased vascular mortality.

Higher mortality was found in the patients with normal weight or obese patients within a year of type 2 diagnosis. This confirms a U-shaped association of BMI in type 2 patients and mortality.

The researchers identified 9,631 deaths between 2001 and 2007. The mortality risk was significantly higher in patients with a BMI 20 to < 25 kg/m² (hazard ratio [HR], 1.22 in men, 1.32 in women) and for patients with a BMI ≥ 35 kg/m² (for example, BMI of 45 to < 50 kg/m²: HR, 1.70 in men, 1.81 in women) compared to patients with a BMI between 25 and 30 kg/m². For every 5 kg/m² increase in BMI above 30 kg/m², vascular mortality increased by 24 percent in men and 23 percent in women. These associations remained significant after adjustment for other variables including glycated hemoglobin.

Diabetes Care April 2013 vol. 36 no. 4 887-893