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Monthly Archives: February 2017

Question 874

Test Your Knowledge

Glucose-lowering drugs and insulin resistance: Which one of the following categories of glucose-lowering drugs improves insulin resistance as its primary mechanism of action? A. Sulfonylureas (e.g. glipizide) B. Thiazolidinediones (e.g. pioglitazone) C. GLP-1 receptor agonists (e.g. liraglutide) D. DPP-4 inhibitors (e.g. sitagliptin) E. SGLT-2 inhibitors (e.g. canagliflozin) Follow the link to see the correct answer!

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Insulin and Extreme Temperatures

We are reviewing a new product that can tell if your insulin has been exposed to extreme temperatures. So can you please answer the question: Have you had any patients whose insulin lost its effectiveness due to being exposed to extreme temperatures? Please follow the link to respond!

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Feb. 21, 2017

We have this great Mexican restaurant that opened a few months ago in South St. Petersburg. The food is fantastic, and the service is amazing; however, because the whole family eats lower carb, we don’t go there as often as we would like. About two months ago, my wife asked …

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Sugar Free, Gluten Free, And Vegan Are NOT Carb Free

Woman, 53 years of age. Type 2 diabetes and is obese. Patient’s daughter was getting married. She was very motivated to lose weight for the wedding and she did. Her A1C lowered from 7.5% to 6.6%. She cut back on her carbs to <100gm/day, increased her activity and took her metformin regularly. She lost 22 pounds over 6 months. The wedding was 2 months ago and she has gained 6 pounds. That may not seem like much, but it was enough to raise her A1C and open her eyes.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #63: Mechanisms of Insulin Signal Transduction Part 7 of 8

Insulin resistance in humans: abnormalities in insulin signaling and in the glucose transport effector system Although the key elements of the insulin signaling network have been defined by studies employing molecular and cell biology techniques, a number of studies have focused on translating this knowledge to human studies in a clinical research setting. Insulin resistance in peripheral tissues characterizes obesity and T2DM, and is involved in the pathogenesis of diabetes.

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Feb. 18, 2017

Sometimes it takes a while to find the missing link when it comes to patient care. When insulin was first used in the 1920s, it was viewed as a cure for diabetes. But as hard as we tried using insulin, we never got to good glucose levels. In the late …

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