Diabetes affects one out of every 20 people on Earth. That equates to almost 347 million people, which is greater than the population of every country in the world except China and India. This infographic from Irish clinic Union Quay Medical Centre gives a well-informed overview of the key points relating to diabetes and tips on how to tackle Type 2 diabetes.

For a patient with an A1c of 5.7% who has been on metformin plus diet and exercise for the last 6 months, would you add another diabetes medication to the patient’s treatment? Follow the link to share your opinion.

Based upon a meta-analysis of cardiovascular outcomes in type 2 diabetes studies, findings suggest that a 15% relative risk reduction in nonfatal myocardial infarcts is associated with an A1C reduction of approximately: a) .50% b) 1.0% c) 1.5% d) 2.0% Did you get it right? Follow the link to find out!

Guest Post by David Kliff, Diabetic Investor Recently we learned the identity of the new British Prime Minister, Theresa May, who, according to a post on www.jdrf.org.uk, is a type 1 diabetic. The post states: “The Home Secretary Theresa May is on course to become the first prime minister who …

Pyruvate cycling pathway is a term I have not heard in many years. When I was in pharmacy school, I remember our Medicinal Chemistry professor posting a slide on the overhead, and telling us if we learned this by the end of the semester we would pass the class. Although …

16-year-old male, type 1 diabetes since 2 years of age, pump therapy. Eats about the same thing daily. Post prandials vary widely. When corrects for highs, gets low.

In part 5, the finale, of this Exclusive Interview, DIC publisher Steve Freed asks about the possibility of expanding the study of the nutritional supplement to address diabetic retinopathy.

In this week's Homerun Slides, part 2 of the Canadian Diabetes Association's specific recommendations for patient-centered diabetes care.

Metabolism-secretion coupling, triggering pathway: Glucose metabolism increases the cytosolic ATP concentration in pancreatic beta cells, this rise in ATP causing closure of the KATP channels and depolarization of the beta-cell membrane. Thus, KATP channels couple the cell’s metabolic state to electrical activity. The beta-cell KATP channel is composed of two subunits: Kir6.2 as a pore-forming subunit and the sulfonylurea receptor SUR1 as a regulatory subunit. Activity of the KATP channel is critical for GIIS. Membrane depolarization opens VDCCs, which allows Ca2+ influx into β cells, the resultant rise in intracellular Ca2+ triggering exocytosis of insulin granules. Thus, KATP channels and VDCCs are major ion channels required for metabolism-secretion coupling in insulin release.

Sixteen years ago when Steve and I started this newsletter, we were sending it out to 30 pharmacists we knew. As more and more of you started subscribing and sharing our site and newsletter with others, I would sometimes sit at my desk in awe of what we had accomplished …