When it comes to metformin, when appropriate, I recommend the extended release version. Last week my patient, female, 56 years of age, type 2 diabetes, visited. A1C was elevated, and she gained 5 pounds. She had been on metformin ER for the last 6 months and doing well. She said she recently noticed a bean-looking/pill-looking thing in her stools that seemed to be related to her metformin.

In part 3 of this Exclusive Interview, Kimberly Ward explains how to get busy healthcare providers to use the information provided by the Accu-Chek system.

In this week's Homerun Slides, debunking the myth that most patients with type 2 will eventually progress to insulin.

Autocrine effect of insulin on insulin secretion: Rodent and human pancreatic beta cells possess the various components of the insulin signaling system, including insulin receptor, insulin-like growth factor-1 (IGF-1) receptor, insulin receptor substrates (IRS-1 and IRS-2), phosphatidylinositol 3-kinase (PI3K), phosphoinositide-dependent kinase-1 (PDK1), and protein kinase B (PKB)/Akt. It has been shown that insulin binds to the insulin receptors on the surface of beta cells and induces phosphorylation of the insulin receptors and IRSs,modulating its own secretion. This effect of insulin is involved especially in the 1st phase of GIIS in mice.

There is an old saying in medicine: “above all do no harm.” This term often comes into play when our patients ask us about nutritional products for diabetes and other diseases, as well as when someone tells us about the greatest new exercise program to “cure” diabetes. This week we …

Is the SGLT-2 inhibitor best used along with metformin, or is canagliflozin as a monotherapy a good choice?

ETC-1002 may offer new therapeutic option that does not decrease glycemic control.

Is there a best time to work out, based on circadian rhythms?

How do consumers and HCPs feel about new technologies and their impact on our health system?

Prevalence of early CKD higher among Hispanics and African Americans.