Beta-Cell function and glucose homeostasis: Insulin secretion, together with the sensitivity to insulin of glucose-utilizing tissues, is a key player in glucose homeostasis. What is relevant for glucose homeostasis is not the absolute insulin secretion levels but insulin secretion relative to glucose, as typically assessed by the beta-cell dose-response during the physiologic condition of oral glucose ingestion. Thus, beta-cell glucose sensitivity is strongly inversely associated to mean glucose levels during a standard OGTT and explains, together with insulin sensitivity, a substantial proportion of the variability in glucose levels.

There have always been conversations amongst medical professionals on the best way to get patients to take the diagnosis of type 2 diabetes seriously. Most of these patients have no symptoms and find out by accident when labs are done or they go to a health fair screening. Because the …

Starting patients diagnosed within the last 7 years on 2-4 weeks of intensive insulin therapy could help keep them off additional medications for at least 48 weeks.

Studies suggest fenofibrate can prevent microvascular changes, decrease need for surgery.

Tighter glucose and blood pressure control found to decrease incidence.

A phase 2 randomized controlled trial demonstrated clinically significant changes in glycemic control.

Metformin use has been associated with significant disturbances in acid-base balance.

Influenza vaccination may reduce cardiac-related hospital admissions and all cause mortality in patients with diabetes.

If the FDA approved, and if it would cause their diabetes to go into remission for 1 or 2 years — giving them time to use lifestyle changes to delay or prevent having diabetes return – would you recommend to your newly diagnosed patients with type 2 diabetes, a 2- or 3-week treatment with insulin twice a day? Follow the link to share your opinion!

Here's another test of your graph-interpreting skills! Follow the link to see this graph at full size and indicate the parameter that best describes Curve 2. 1. Insulin Secretion 2. Postprandial glucose 3. Fasting glucose 4. Insulin Resistance