Yohimbine, a α2A-adrenergic receptor agonist, showed a 29% increase in insulin secretion in patients with type 2 diabetes related to the genetic variation… The feasibility of exploiting genomic information for individualized treatment of polygenic diseases remains uncertain. A genetic variant in ADRA2A, which encodes the α2A-adrenergic receptor (α2AAR), was recently associated with type …

The researchers found that dietary iron plays an important role in the circadian clock of the liver. “Iron is like the dial that sets the timing of the body clock,” said lead author Judith Simcox from the University of Utah in the US. The liver’s circadian clock is set by …

Type 2 diabetes patients exhibited a weak ability to regulate blood pressure, cholesterol and heart rate when they experienced stress, a new study showed. Researchers also noted increased depressive and hostile symptoms in these patients. The researchers looked at the biological systems of 140 patients with type 2 diabetes and …

Cleveland Clinic researchers found that high-intensity statin treatment was associated with coronary atheroma regression in patients with or without diabetes, suggesting the therapy may halt the progression of diabetic coronary atherosclerosis. Coronary atheroma volume was measured using serial intravascular ultrasound in patients treated with rosuvastatin 40 mg or atorvastatin 80 …

Trulicity Once-Weekly GLP-1 Shipping Now  Eli Lilly and Company announced that Trulicity, a glucagon-like peptide-1 receptor agonist (GLP-1 RA) with once-weekly dosing in the Trulicity pen, was approved by the FDA on September 18, 2014, and is shipping to distributors now.

Glutamine is the most abundant amino acid in the human body and is involved in more metabolic processes than any other amino acid. Recent studies using isotopic and balance techniques have greatly advanced the understanding of glutamine metabolism in humans and its role in glucose metabolism in the kidney and other …

Sometimes it seems as if we don’t talk about an organ or a problem until we have a medication to treat it. For years we didn’t consider the kidney as a problem area for diabetes. It was not until we identified the SGLT-1 and -2 receptors that we began to …

Each week there seem to be articles, studies, and clinical treatises that draw a link between diabetes and cardiovascular disease. If you look through all these documents, the benchmark for measurement always seems to be A1c. However, if you were to take a look at this week’s Homerun Slides from …

In this week’s Homerun Slides, courtesy Dr. Stanley Schwartz, we continue our examination of diabetes from a cardiologist’s perspective with topics including the Factors Contributing to Cardiometabolic Risk and the Pathophysiology of Diabetic Complications: Implications for Goals of Therapy…. To download the complete set of these slides in PowerPoint (.ppt) …

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP Diabetic eye disease primarily affects the retinal vasculature, but the iris and lens can also be involved. Most people with diabetes will show signs of retinopathy after 25 years duration, but only a minority progress to the severest form. Photocoagulation has revolutionized …