The once-daily oral tablet is the first in the U.S. to combine the SGLT-2 inhibitor dapagliflozin with the biguanide extended-release (XR) metformin hydrochloride.. The US Food and Drug Administration (FDA) has approved a once-daily combination of dapagliflozin and metformin hydrochloride extended-release (Xigduo XR, AstraZeneca) for the treatment of adults with …

The overall risk of metabolic syndrome decreased with every 100 mg per day increment in magnesium intake…. Previous studies have shown conflicting accounts of how beneficial dietary magnesium intake is in decreasing the risk of metabolic syndrome. The purpose of this meta-analysis was to determine the association between metabolic syndrome …

The addition of a DPP-4 inhibitor decreased HbA1C while not requiring an increase in insulin, and subjects remained weight neutral without experiencing an increase in hypoglycemic events… Currently approved dipeptidyl peptidase-4 (DPP-4) inhibitors include alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin. DPP-4 inhibitors work by enhancing glucose dependent insulin secretion and …

Type 2 diabetes patients were more likely to have lower stress reactivity and impaired stress recovery when compared to healthy subjects… Stress-related factors are thought to play a role in the development of type 2 diabetes. Such factors have an impact on metabolic, cardiovascular and inflammatory regulation. Previous studies have …

Physical activity intervention had a positive impact on reducing HbA1c, BMI and total cholesterol but insulin dosage did not change in the study… Due to the increased risk of cardiovascular disease in type 1 diabetes patients, physical activity is advised. This recommendation is used in combination with insulin therapy and …

Metformin, sulfonylureas, thiazolidinedione, and DPP-4 inhibitors were compared to evaluate the effects on the time to subsequent treatment… There are many classes of oral drugs used for diabetes therapy, but there is a lack of evidence as to which drug is best for use as initial therapy. Most patients diagnosed …

European scientists studying addiction have found that there is almost no evidence showing humans can be addicted to specific macronutrients such as sugar. Instead, the researchers suggest that obesity prevention strategies should focus on an "eating addiction," rather than specific foods. Neuroscience & Biobehavioral Reviews DOI: 10.1016/j.neubiorev.2014.08.01

Developed by Stanford University School of Medicine researchers, the skin patch has an array of microneedles to painlessly poke holes in the top layer of skin, gradually releasing medication. The main ingredient of the medication, deferoxamine, helps to promote the growth of new networks of small blood vessels needed to …

High blood glucose levels over a long time might be responsible for aortic valve calcification…

Patients with diabetic peripheral neuropathy were slower and clumsier than their healthier counterparts when going up and down stairs due in part to weak muscles, poor coordination and sensory damage, according to a study. However, researchers said resistance training may help patients build up strength and reduce the risk of …