In this week’s Homerun Slides, we delve into the mechanisms of action of SGLT-2 Inhibitors and look at some of the studies involving animal models and what came out of those studies…. To download the complete set of this week’s slides, just use this link: Role of the Kidney, Part 8 …

Rudy Bilous MD, FRCP Richard Donnelly MD, PHD, FRCP, FRACP   Diabetes mellitus is diagnosed by identifying chronic hyperglycemia. The World Health Organization (WHO) and the American Diabetes Association (ADA) have used a fasting plasma glucose (FPG) of 126mg/dL.(7 mmol/L) or higher to define diabetes (Table 3.1 ). This originated from epidemiological …

When the first SGLT-2 inhibitor came to the market we went to doctors all over the country and asked them their opinions on this new class of drugs. The overwhelming response was "wait and see." Now a year later we asked them again to tell us how they feel about …

When the first SGLT-2 inhibitor came to the market we went to doctors all over the country and asked them their opinions on this new class of drugs. The overwhelming response was “wait and see.” We went back to them 3 months later and although some of them had tried …

FDA accepts application for Sanofi’s New Basal Insulin, Toujeo 

Obese adults are more likely to die from all causes than those within normal weight range, but particularly from heart disease, cancer and diabetes. The meta-analysis of 20 prospective cohort studies found life expectancy decreased as BMI surpassed 40. "Our results suggest that otherwise healthy, non-smoking adults with BMI values …

Eating instant noodles more than twice weekly was associated with an increased prevalence of metabolic syndrome regardless of dietary patterns according to a team of researchers from Harvard University in Boston, Massachusetts, and Eulji University in Korea. Recognizing that "the consumption of instant noodles is relatively high in Asian populations," …

And consuming whey protein may even help increase insulin production. "Consumption of whey protein shortly before a high-glycemic index breakfast increased the early and late post-meal insulin secretion, improved GLP-1 responses and reduced post-meal blood sugar levels in type 2 diabetic patients," the authors wrote. "Whey protein may therefore represent …

As patients become older, they become more vulnerable to the risk of side effects that are present with diabetic medications…. 

Dominant-hand psychomotor impairment in speed was significantly associated with poor glycemic control….