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Cardiovascular


Cardiovascular Health and Diabetes

Diabetes is an inflammatory, cardiometabolic disease. It elevates nearly every cardiovascular risk factor, and most diabetes patients will die from cardiovascular disease. However, insights from new clinical research along with patient education provide new edges to improve cardiovascular outcomes in your diabetes patients. Learn more here and in our weekly newsletters.

Table of Contents

Articles

Longer Working Hours Associated with Higher Type 2 Incidence

Socioeconomic status plays a role in how strong the association is....


Gastric Bypass Better than Gastric Band for Long-Term Results

Gastric bypass surgery shows better outcomes for long-term weight loss, controlling type 2 diabetes, hypertension, and cholesterol level....


Empagliflozin May Reduce Blood Pressure for Type 2s

Empagliflozin use in the management of glucose in type 2 diabetes could reduce blood pressure in patients with hypertension....


Handbook of Diabetes, 4th Ed., Excerpt #13: Control and Complications

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP  


Tight Blood Sugar Control May Not Be Needed for Heart Bypass

Survival rates similar for those with looser glucose limits.... 


EASD: Insulin Pumps Lower Mortality Rate 29% Compared to Multiple Injections in T1DM

And fatal cardiovascular disease risk is 43% lower for type 1 diabetes patients using insulin pumps over multiple daily injections.... 


EASD: Type 2 Diabetes plus Ischemic Heart Disease Can Predict Mortality

Long-term mortality of patients with ischemic heart disease is independently predicted by diabetes....


No Mortality Reduction in Type 2 Diabetes with Tight Glycemic Control

No effect of tight glycemic control on mortality or major cardiovascular events in long-term follow-up of the ADVANCE trial.... 


No Risk Seen of CHF with Incretin-Based Drugs in T2DM

A large study in the UK looked at the long-term effects of GLP-1 and DPP-4 therapy on patients' risk of congestive heart failure....


Effect of Low HDL Cholesterol on Cancer Risk in Type 2 Diabetes Patients

Low HDL increases the risk of heart disease but does it also increase the risk of cancer?...


Statins May Protect against Microvascular Complications of Diabetes

Complications that can lead to blindness, nerve damage, and kidney damage could be reduced by taking statins.... 


High-salt Diet and High HBA1c May Increase Cardiovascular Disease

A synergistic effect may exist between HbA1c level and dietary sodium intake for the development of CVD.... 


Fibrates Can Reduce Cardiovascular Risk in Type 2's

This study showed that fenofibrate was very effective in lowering total, LDL, non-HDL cholesterol significantly in female diabetic patients compared to male patients.... 


LX4211 Improved Glucose Control without Dose-Increasing Glucosuria in Type 2 Diabetes

In patients with type 2 diabetes, LX4211 produced greater dose-ranging effects on HbA1c than on glucosuria.... 


Diabetic Coronary Atherosclerosis Regression Seen with High-Intensity Statin Therapy

High-intensity statin therapy altered the progressive nature of coronary atheroma in diabetic and nondiabetic patients....


FDA Approves Bupropion/Naltrexone (Contrave) for Obesity by Orexigen Therapeutics

The FDA first rejected the drug combination in February 2011, asking the company to conduct a cardiovascular-outcomes trial because of concerns about the CV safety profile of bupropion/naltrexone when used long-term in a population of overweight...


Long-term Use of Sulfonylureas and the Risk of CVD

Diabetic women who use sulfonylureas for a long time could have a higher risk of developing CHD.... 


Coffee a Prediabetes Risk Factor for Young Adult Patients with Hypertension

Slow caffeine metabolizers who drink more than three cups a day have the highest risk.... 


New Lipid Guidelines Lead to Modest Increase in Statin Use

The contentious American Heart Association and American College of Cardiology guidelines, which stirred controversy when unveiled last year, more accurately matched statin assignment to plaque burden compared with older guidance, leading to a...


Diabetes Increases Risk of Atrial Fibrillation

Adults with diabetes are at increased risk of subsequent new-onset atrial fibrillation – and the younger the age at diabetes onset, the greater the likelihood of developing the arrhythmia.... 


Predicting Which Diabetics Will Develop Major Complications

A new model is presented for predicting which patients with type 1 diabetes will go on to develop major complications.... 


Diet and Physical Activity Reduce Inflammatory Markers in Type 2

Both diet and diet plus physical activity interventions reduced inflammatory markers soon after type 2 diagnosis....


Hypertension Control Can Prevent Renal Damage in Diabetics

Elevated blood pressure is associated with an increased risk of renal damage in patients with type 2 diabetes, especially if they have poor glycemic control.... 


Effects of Intensive Glycemic Control on Ischemic Heart Disease

How can three landmark trials of intensive vs standard glucose-lowering strategies -- ADVANCE, ACCORD, and VADT -- raise more questions than they answer?... 


Peripheral Neuropathy Associated with CV Disease and Stroke in Type 2 Diabetes Patients

Testing for peripheral neuropathy may provide a way to identify individuals at higher risk of cardiovascular events.... 


Acarbose Treatment and the Reduction of CVD Risk in Type 2 Diabetes Patients

Previous studies have shown that decreasing postprandial hyperglycemia with acarbose could reduce the risk of CV events but a new study shows that risk may increase for the first 12 months of exposure…. 


Gender Differences in Control of Multiple CVD Risk Factors in Type 2 Diabetes Patients

Adjusted mean DBP levels found to be significantly higher in women compared to men but other risk factors were almost the same between genders….


Metformin Treatment Provides Better Lipid Control

Better overall lipid effects were seen in type 2 diabetes patients with coronary artery disease treated with metformin than those being treated with glipizide....


Hypertension Control Can Prevent Renal Damage in Diabetics

Elevated blood pressure is associated with an increased risk of renal damage in patients with type 2 diabetes, especially those with poor glycemic control....


Fruits and Vegetables: How Much Consumption is Enough?

In a large meta-analysis of over 800,000 participants' dietary habits, researchers concluded….


Regression from Prediabetes to Normal Glucose Reduces CVD Risk

But risk for CVD was higher in the prediabetes group than for those who already had diabetes, probably due to increased medication…. 


Salty Diet Tied to Heart Risk in Type 2 Diabetes

Patients in the top quartile of salt consumption had a 2.07-fold higher risk of CVD than the lowest quartile.... 


Statin Adherence Linked to New Onset Diabetes Risk

Italian researchers find correlation….


HbA1c Variability and Mortality in Patients with Type 2 Diabetes

HbA1c variability is a predictor of all-cause mortality....


Painful Neuropathy and Increasing Blood Pressure

Painful diabetic neuropathy (PDPN) has been associated with higher nocturnal blood pressure in patients....


Can Bundled Therapy Reduce Risk of Vascular Complications?

Under a new system of care, diabetes-related macro- and microvascular complications. are managed as well as glucose control... 


Obesity May Shorten Life by 14 Years

Adults with extreme obesity have increased risks of dying at a young age from cancer and many other causes including heart disease, stroke, diabetes, and kidney and liver diseases.... 


Sitagliptin Use in Diabetic Patients with Heart Failure

There is some uncertainty in the literature about whether DPP-4 inhibitors are harmful to diabetic patients with heart failure.... 


Association between Diabetic Foot Ulceration and Premature Death

Evidence is emerging that diabetic foot ulceration is associated with greater risk of premature death.... 


ADA: The New Lipid Guidelines, Do They Work for Diabetes?

Some diabetes experts have expressed concerns about recent national guidelines on lipid management, criticizing a lack of LDL cholesterol targets and little direction for management with drugs beyond statins.... 


ADA: LDL Doesn't Predict Heart Risk in Diabetes

LDL cholesterol wasn't a good predictor of cardiovascular disease in type 1 diabetes, but the total cholesterol-to-HDL ratio appeared more reliable, an observational study showed.... 


ADA: Prediabetes Intervention Cuts Cardiovascular Risk

Treatment of prediabetes and prevention of type 2 diabetes reduces cardiovascular risk.... 


ADA: Canola Oil Reduces Heart Risk in Diabetes

Adding canola oil to the diet improved glycemic control and reduced cardiovascular risk in type 2 diabetes. And in another study, an overall healthier diet reduced risk of developing diabetes....


Bariatric Surgery Has Better Outcomes after 15 Years

Bariatric surgery comes out ahead with greater weight loss, diabetes remission and less CVD complications than standard medical care.... 


Adding Insulin as the Second Treatment for Type 2's May Increase Risk of Death

Among diabetes patients receiving metformin, the addition of insulin compared with a sulfonylurea was associated with an increased risk of nonfatal cardiovascular outcomes and all-cause death.... 


Blood Pressure Therapies May Be Causing Serious Eye Conditions

Early studies are showing that the use of vasodilators to lower BP may be related to development of early-stage age-related macular degeneration....


Diabetes Often Times Overlooked after Heart Attack

At least ten percent of people who have a heart attack may also have undiagnosed diabetes.... 


Improved Quality of Life with Ranolazine

Patients with diabetes and stable angina may reap the benefits of ranolazine.... 


Increased Platelet Activation leads to CV Risk in Adolescents with Type 2 Diabetes

Adolescents with type 2 diabetes are at risk of atherosclerosis and cardiovascular disease early on in life.... 


Which Comes First: Heart Attacks or Diabetes?

Ten percent of patients were newly diagnosed with diabetes while being treated for their heart attack.... 


Cardiac Death Risk in Diabetic Hemodialysis Patients Increased Due to Thyroid Problems

A prospective study found that diabetic hemodialysis patients' subclinical hyperthyroidism and euthyroid sick syndrome might increase the risk of sudden cardiac related deaths.... 


Joslin's Diabetes Deskbook, Updated 2nd Ed., Excerpt #49: Pharmacotherapy of Type 2 Diabetes, Part 8

Richard S. Beaser, MD


Heart Risk and Death between 40% and 50% Greater for Women with Diabetes

Women with diabetes were at 40% to 50% greater risk for developing and dying from coronary heart disease than diabetic men, and sex disparities in pharmacotherapy didn't appear to explain the excess risk.... 


Losing Weight at Any Age Can Improve Cardiovascular Health

Weight loss at any age in adulthood is worthwhile because it could yield long-term heart and vascular benefits.... 


Reduced Systolic Blood Pressure Observed with Liraglutide

The reduced SBP was also weakly correlated with weight loss....


Aspirin Delays Wound Healing

New published research describes how aspirin acts on key skin cells called keratinocytes, delaying skin repair at wound sites....


Update: GLP-1 Analogs and Cardiovascular Health

David Joffe, BSPharm, CDE The cardiovascular morbidity and mortality associated with diabetes are well established, so much so that type 2 diabetes has been described as a cardiovascular...


AACE: Prediabetes Guidelines for Lipids and Blood Pressure Levels

Call for guidelines for prediabetes from the Clinical Endocrinologists meeting....


High-normal A1c Signals CAD Risk in Nondiabetic Patients

Among patients who don't have diabetes, high-normal HbA1c levels (at or above 5.8%) are strongly correlated with the risk of coronary artery disease.... 


Intensive Insulin Therapy Prolongs Life in Post-Acute Myocardial Infarction Diabetes Patients

Intensive insulin treatment extended life by more than two years after acute myocardial infarction (AMI) in patients with diabetes compared with standard treatment....


FDA - Stop Using Aspirin for Patients with No History of Heart Disease

The Food and Drug Administration last week stated that aspirin should not be used for stroke or heart attack prevention in people with no history of heart disease.... 


The Potential of Low-Carbohydrate Diets to Reduce CVD Risk

Consuming low-carbohydrate diets can reduce inflammation in patients with type 2 diabetes which may decrease the risk of patients developing cardiovascular disease.... 


FDA Approves Epanova, a Different Form of Omega-3

AstraZeneca has announced that the US Food and Drug Administration (FDA) has approved Epanova (omega-3-carboxylic acids) as an adjunct to diet to reduce triglyceride levels in adults with severe hypertriglyceridaemia (triglyceride levels greater...


Resveratrol May Not Be Associated with Improved Health

The antioxidant resveratrol, found in red wine, chocolate and grapes, was not associated with longevity or the incidence of cardiovascular disease, cancer and inflammation in a new study.... 


Statin Users Show Higher BG Levels

Monitoring blood glucose in hypertensive patients may be beneficial for optimal glycemic control.... 


Synergistic Anti-inflammatory Effect with Pioglitazone and Simvastatin

Pioglitazone and simvastatin combined may have a positive effect on atherosclerosis.... 


OGTT for Identifying Diabetes in Chronic Heart Failure

Oral glucose tolerance tests may be more useful than HbA1c in chronic heart failure patients.... 


Graded Association between Stroke Risk and HbA1c for Women

A graded association between HbA1c and stroke risk may exist among women.... 


Men and Women May Respond Differently to Popular Diabetes Medications

New information on gender specific responses may help with more patient-specific prescribing.... 


Rates of Diabetic Heart Attacks and Strokes Fall 60%

Diabetes rate is increasing while diabetes-related complications are decreasing.... 


Fatty Liver Disease Tied to Diabetes, Atherosclerosis

Non-alcoholic fatty liver disease (NAFLD) is an independent predictor of both type 2 diabetes and carotid atherosclerosis, according to two studies.... 


AHA Questions Salt Intake Study

The American Heart Association questions the findings of a new analysis suggesting that most people around the world are consuming just the right amount of sodium.... 


Vitamin D Not Linked with Heart Risk in Men

Circulating levels of vitamin D had no apparent influence on overall risk for cardiovascular disease in older men.... 


Benefits of ARBs Not the Same as ACE Inhibitors

The effects of ACEIs and ARBs on multiple outcomes in type 2 diabetes patients.... 


Negative Outcomes Associated with Inter-arm Systolic Blood Pressure Differences in Diabetes Patients

Inter-arm systolic blood pressure differences may be a sign of bad things to come....


Lifestyle Changes during Prediabetes Can Reduce Mortality

Not only may an intensive program of diet, exercise, or both delay progression from prediabetes to diabetes, but among women, it may also lower CVD and all-cause mortality.... 


Diabetes and CVD Risk with Postpartum Weight Gain

Failure to lose 'baby weight' may carry long-term risk for diabetes and heart disease.... 


Aleglitazar Does Not Reduce Risk of Recurrent CV Events among Diabetes Patients

The use of aleglitazar does not appear to reduce the risk of cardiovascular events in diabetic patient.... 


Diabetes Clinical Case Series, Excerpt #8, Endocrinology and Diabetes

Oliver, aged 46, is found to have...


Diabetes Clinical Case Series, Excerpt #6, Endocrinology and Diabetes

Ramzi Ajjan, MRCP, Med Sci, PhD


Dissecting Dietary Determinants of Atherogenic Dyslipidemia and Targeting the Culprit Particles

Joy Pape, RN, BSN, CDE, WOCN, CFCN, FAADE Dr. Ronald Krauss, MD, Senior Scientist and Director of Atherosclerosis Research at...


Joslin's Diabetes Deskbook, Updated 2nd Edition, Excerpt #32: Macrovascular Complications, Part 4

Richard S. Beaser, MD Michael Johnstone, MD


Joslin's Diabetes Deskbook, Updated 2nd Edition, Excerpt #31: Macrovascular Complications, Part 3

Richard S. Beaser, MD Michael Johnstone, MD


Joslin's Diabetes Deskbook, Updated 2nd Edition, Excerpt #30: Macrovascular Complications, Part 2

Richard S. Beaser, MD Michael Johnstone, MD


Top Ten Things to Know: 2011 Effectiveness-Based Guidelines for the Prevention of CVD in Women

  In 2007, CVD caused about 1 death per minute among women in the US.


Top 10 Sodium Overkill Culprits (Patient Handout)

  Nine out of 10 Americans consume more sodium than they need, according to a new report...


Why Heart Rate Variability Is Key to Longevity and Healthy Aging

 


SPECIAL FEATURE: GLP-1 Agonist-based Therapies: An Emerging New Class of Antidiabetic Drug With Potential Cardioprotective Effects

Melanie Sulistio, MD, Curtis Carothers, MD, Mandeep Mange, BS, Mike Lujan, BS, Rene Ofiveros, MD, and Robert Chilton, DO PART 2: GLP 1 Agonist-based Therapies: How do they reduce...


United States of Diabetes Report

  You can use the information in this report to provide evidence for your ...


Psychology in Diabetes Care, 2nd. Ed, Part 9

Edited by Frank J. Snoek and T. Chas Skinner Diabetes in Adolescents


Managing Clinical Problems in Diabetes, Case Study #9: Mrs. MS

Edited by Trisha Dunning AM, RN, MEd, PhD, CDE, FRCNA and Glenn Ward MBBS, BSc, DPhil (Oxon), FRACP, FRCPath


Body Fat Calculator

  People ...


PRADAXA (DABAGATRAN), A New Anticoagulant for Stroke and Embolism Prevention

By Jennifer Freidman 2011 Doctor of Pharmacy Candidate, University of Florida Atrial fibrillation currently affects about 2.2 million Americans. If left untreated it can cause embolism ...


Diagnosis and Management of Type 2 Diabetes, 10th Edition, Ch 15, Pt2

Long-Term Complications and Treatments: Dyslipidemia


New Product: How high is your blood pressure? Ask your iPhone‎

How high is your blood pressure? Ask your iPhone‎ iHealth Lab has announced the iHealth...


A Year of Diabetes Research 2010

Prevention, therapy and complications are the keystones for diabetes research. It would be impossible to cover all of the developments in just one feature. So here is a brief summary of some of the best for 2010.


Editor's Note: Diabetes and Cardiovascular Disease, Lifestyle Habit Changes, and More....

Every week there is a new study coming out showing the relationship between diabetes and cardiovascular disease. There are over 1.1 million Americans who will have a serious heart attack in 2011 and there are over 80 million who have one or more...


Hyperglycemic Emergencies

Lana Kravarusic Doctor of Pharmacy Candidate, University of Florida 


Letter from the Editor, August 29, 2010: Popeye vs Wimpy

It appears there is a classic battle brewing between Popeye and Wimpy as to what works better for your health.  Popeye thinks he was right when he said, "I'm strong to the finich, 'Cause I eats me spinach," as a new study of over 220,000...


Heart Risk from Actos® as Great as from Avandia®, Study Suggests

According to a study published in Circulation: Cardiovascular Quality and Outcomes, the heart risk from Actos is just as great as the risk posed by Avandia according to a story published Tuesday, August 24 by the Los Angeles...


Essential Oils for the Management of Type 2 Diabetes

Ivory A. Gordon, Pharm.D....


America's Silent Killer: Oprah and Dr. Oz Want to Save Your Life

By...


Preventing Medication Errors

Institute for Safe Medication Practices


The Glucose – CVD Connection: The Search For The Missing Link

There is a new study out trying to show the link between intensive glycemic control and reductions, if any, in cardiovascular endpoints. The VA Diabetes Trial of 1,800 patients, showed like other, larger trials recently published, that there was no...


The Message for World Kidney Day 2009:

Hypertension And Kidney Disease: A Marriage That Should Be Prevented is the message for WORLD KIDNEY DAY 2009 and we have a special feature written jointly by Eberhard Ritz representing the International Society of Nephrology (ISN) and George...


HIV-infected patients are at an increased risk for developing Diabetes

More and more patients with HIV are controlling their disease well. When viral loads are under control, patients often are seen by clinicians for other problems. Diabetes seems to be one of those problems that get a lot of attention. My current...


Risks for Drug Induced Pancreatitis

With all the press lately about the incretin mimetics and pancreatitis our current intern, Jennifer Webb, PharmD Candidate, FAMU has taken a look at the facts, and compared the chances of pancreatitis among classes of drugs and how the risk of...


Charcot Foot: A Potenial Risk Factor for Diabetic Patients

Charcot Foot: A Potential Risk Factor for Diabetic Patients, is a valuable report on an under diagnosed problem written by Jennifer Webb, Doctor of Pharmacy Candidate, FAMU. You may want to print this out and hand it to your patients.


Presentations

Diabetes Mellitus 101 for Cardiologists Part 1

  In this week's slides series, courtesy Dr. Stanley Schwartz, we review some of the basics of diabetes mellitus...


Therapy of Type 2 Diabetes Mellitus, Update, Part 2

  In this week's set of Homerun Slides from Dr. Stanley Schwartz, we delve into the current state...


Quality Measures In Cholesterol and Diabetes Management, Part 1 of 4

  This week we have the first set of slides in a three-part series examining current treatment practices...


Hypertension in the Medicare Population, Part 2 of 2

In this second set of Homerun Slides on Hypertension in the Medicare Population, we review some...


Hypertension in the Medicare Population, Part 1 of 2

  In this week's Homerun Slides set, we take a look at the challenges posed by an increasingly...


Achieving Glycemic Control in the Hospital Setting, Part 3 of 4

In this week's set of Homerun Slides, our topics include IV Insulin Protocols, Considerations when...


Diabetes Mellitus 101 for Medical Professionals, Part 5 of 9

In this week's Homerun Slides, we cover such topics as the Potential Mechanisms of...


Diabetes Mellitus 101 for Medical Professionals, Part 2 of 9

In this week's set of Homerun Slides,...


Sleep Apnea

If your diabetes patients have sleep apnea, they may also have hypertension....


Diabetes Microvascular Complications, Part 1 of 2

Diabetes mellitus can lead to many acute and chronic complications. The chronic...


Understanding Acute Coronary Syndrome

Over twelve and half million Americans currently have heart disease and 1.1 million...


Insulin Resistance, Part 2 of 3: Inflammation Markers

Plasminogen is an acute phase protein and precursor to plasmin, which...



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Do your teenage patients manage their diabetes well?
CME/CE of the Week
Wade Farrow, MD, CWS, FCCWS

Category: Vascular Therapy
Credits: 1


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