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Weekly Semaglutide vs. Daily Sitagliptin in T2D Patients  

Nov 17, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Abdullah Al-Ajmi, PharmD Candidate, Skaggs School of Pharmacy and Pharmaceutical Sciences

One diabetes drug showed superior results for A1C reduction and weight loss.  

Semaglutide (Ozempic®) is approved as a once-weekly GLP-1 RA for T2DM. It achieved its long-acting effect by adding two amino acids and one fatty acid chain, which leads to increased protein binding, thus increasing its half-life.  Semaglutide has been proven to be effective in multiple studies compared to placebo and other antidiabetic therapies. It was reported to be effective in reducing A1C and BMI compared to the placebo. Additionally, it was reported that it had a significant reduction in the rate of major adverse cardiovascular events (MACE).  

This study aims to compare semaglutide once weekly to sitagliptin once daily in a Chinese population, and to compare its findings to the SUSTAIN trials that included a global community....

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