Senior author Sundeep Khosla, M.D., Mayo Clinic endocrinologist, stated that the skeleton should be recognized as another important target of diabetes complications. In a clinical study of 60 postmenopausal women, 30 of whom had type 2 diabetes, researchers performed micro indentation testing of the tibia to measure bone material strength. Compared to the control group of women, aged 50 to 80, the group with type 2 diabetes had significantly lower bone material strength. The study showed that diabetic women with lower bone material strength also experienced higher levels of hyperglycemia over the previous 10 years, suggesting potential detrimental effects of poor glucose control on bone quality. Journal of Bone and Mineral Research, Nov. 2013
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