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Tag Archives: renal outcomes

Beyond SGLT2 Inhibitors: Why Non-Steroidal MRAs Are Becoming the Third Pillar of Kidney Protection

Illustration of healthy kidneys with medication representing non-steroidal mineralocorticoid receptor antagonists alongside SGLT2 inhibitor therapy for diabetic kidney disease management.

For years, the treatment of diabetic kidney disease focused primarily on glycemic control and blood pressure management. More recently, SGLT2 inhibitors and GLP-1 receptor agonists have transformed the landscape by reducing kidney disease progression and cardiovascular events. However, another therapeutic class is rapidly gaining recognition. Non-steroidal mineralocorticoid receptor antagonists (MRAs) …

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GLP-1s and CKD Progression: Are Anti-Inflammatory Effects Clinically Meaningful?

Medical illustration of kidneys with GLP-1 therapy pen and molecular model representing GLP-1 CKD progression and anti-inflammatory kidney effects

Chronic kidney disease (CKD) remains one of the most serious complications associated with diabetes, affecting millions of patients worldwide. While SGLT2 inhibitors have become foundational therapies for protecting kidney function, researchers are increasingly examining whether other drug classes may also slow renal decline. In particular, growing interest surrounds how GLP-1 …

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