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Tag Archives: CKM syndrome

GLP-1s and Cardiometabolic Risk in Normal-Weight Patients: Is BMI the Wrong Gatekeeper?

GLP-1 injection pen with cardiometabolic risk report and healthy foods representing metabolic health in normal-weight patients

GLP-1 receptor agonists have reshaped the management of type 2 diabetes and obesity. However, growing interest now surrounds the potential role of GLP-1 therapy in normal-weight patients with cardiometabolic risk and whether treatment decisions should rely less on BMI alone. While body mass index remains a widely used screening tool, …

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Early Combination Therapy in Type 2 Diabetes: Is Monotherapy Becoming Obsolete?

Physician discussing early combination therapy options for type 2 diabetes with patient, including metformin and SGLT2 inhibitor medications.

When managing type 2 diabetes, should clinicians still begin with one medication and wait for treatment failure before intensifying therapy? Increasingly, evidence suggests that early combination therapy in type 2 diabetes may provide better durability, faster glycemic control, and improved cardiovascular and kidney outcomes in high-risk patients. While metformin monotherapy …

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